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Merck

P9180

Procaterol hydrochloride

β2 adrenoceptor agonist, powder

Sinónimos:

erythro-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone

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About This Item

Fórmula empírica (notación de Hill):
C16H22N2O3 · HCl
Número CAS:
62929-91-3
Peso molecular:
326.82
NACRES:
NA.77
PubChem Substance ID:
24899017
UNSPSC Code:
12352202
EC Number:
263-763-0
MDL number:
MFCD04221378

Nombre del producto

Procaterol hydrochloride,

InChI key

AEQDBKHAAWUCMT-CVHDTDHSSA-N

InChI

1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1

SMILES string

Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12

form

powder

storage temp.

2-8°C

Quality Level

200

Categorías relacionadas

Biochem/physiol Actions

β2-adrenoceptor agonist; bronchodilator.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCBZ8090
BCBN8424V
BCBJ5050V
1399480V
1399034

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Visite la Librería de documentos

Y Yamazaki et al.
British journal of pharmacology, 124(3), 593-599 (1998-07-01)
1. The beta-adrenoceptor (beta-AR) subtypes mediating relaxation of the rabbit, rat and canine detrusors were subjected to functional investigation using selective beta-AR agonists and antagonists. 2. In all three species, isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of
Nobuyo Komatani-Tamiya et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 29(3-4), 511-522 (2012-04-18)
The beating cilia play a key role in lung mucociliary transport. The ciliary beating frequency (CBF) and ciliary bend amplitude (CBA) of isolated mouse bronchiolar ciliary cells were measured using a light microscope equipped with a high-speed camera (500 Hz).
Ching-Hua Huang et al.
Pediatric pulmonology, 45(10), 977-984 (2010-07-31)
Procaterol is a β2-adrenoceptor agonist used as a bronchodilator for the treatment of asthma; it also possesses an anti-inflammatory property. As chemokines play a pivotal role in inflammation and the pathogenesis of asthma, we investigated the effects of procaterol on
Immune System Diseases: New Insights for the Healthcare Professional (2012)
Yukiko Hiraguchi et al.
International archives of allergy and immunology, 155 Suppl 1, 85-89 (2011-06-10)
Viral respiratory tract infections play an important role in the inception and exacerbation of asthma. Eosinophils, major effector cells in asthma, often accumulate in the airways during viral infections and are possibly activated by respiratory RNA viruses through Toll-like receptor
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