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R1512

Retinyl palmitate

potency: ≥1,700,000 USP units per g

Sinónimos:

Vitamin A palmitate, all−trans−Retinol palmitate

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Fórmula empírica (notación de Hill):
C36H60O2
Número CAS:
79-81-2
Peso molecular:
524.86
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
24899347
EC Number:
201-228-5
Beilstein/REAXYS Number:
1917366
MDL number:
MFCD00019414
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biological source

synthetic (organic)

Quality Level

200

form

solid or viscous liquid

potency

≥1,700,000 USP units per g

does not contain

antioxidant

color

yellow to yellow-green

mp

26 °C

storage temp.

2-8°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1

InChI

1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+

InChI key

VYGQUTWHTHXGQB-FFHKNEKCSA-N

General description

Retinyl palmitate or vitamin A palmitate is a retinoid, which is an acid form of vitamin A. Retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinyl palmitate is a major storage form of vitamin A found in epidermis. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed.

Application

Retinyl palmitate has been used as a standard in high performance liquid chromatography (HPLC). It has also been used to study its effect on brain regeneration in larval Xenopus laevis.

Biochem/physiol Actions

Review: Vitamin A metabolism.
Retinyl palmitate is widely used in pharmaceutical applications. It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties. Retinyl palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration. It is added as a source of vitamin A in low fat and skim milks. Retinyl palmitate acts as a chemopreventive or antineoplastic agent.

Packaging

Sealed ampule.

Physical form

oil or solid

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
MKCW1325
MKCQ1921
MKCM3866
MKCH2206
MKCB0566V

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Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging
Oliveira MB, et al.
BioMed Research International (2014)
Anticancer activity and mechanism of action of retinoids in oral and pharyngeal cancer
Klaassen I and Braakhuis BJM
Oral Oncology, 38(6) (2002)
Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A) during percutaneous absorption
Boehnlein J, et al.
Pharmaceutical Research, 11(8), 1155-1159 (1994)
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