R7150
Ro 25-6981 hydrochloride hydrate
≥98% (HPLC), powder
Sinónimos:
(αR)-(4-Hydroxyphenyl)-(βS)-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate
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Fórmula empírica (notación de Hill):
C22H29NO2 · HCl · xH2O
Número CAS:
Peso molecular:
375.93 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: >20 mg/mL
originator
Roche
SMILES string
O.Cl.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3
InChI
1S/C22H29NO2.ClH.H2O/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H;1H2/t17-,22+;;/m0../s1
InChI key
FEINQVNMUYISNW-HVDCVHHPSA-N
Gene Information
human ... GRIN2B(2904)
Application
Ro 25-6981 hydrochloride hydrate has been used:
- as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
- as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
- to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus
Biochem/physiol Actions
Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Ya-Bing Zhu et al.
Journal of neuropathology and experimental neurology, 79(7), 800-808 (2020-05-10)
The mechanisms underlying type-2 diabetic neuropathic pain (DNP) are unclear. This study investigates the coupling of postsynaptic density-95 (PSD-95) to N-methyl-D-aspartate receptor subunit 2B (GluN2B), and the subsequent phosphorylation of GluN2B (Tyr1472-GluN2B) in the spinal cord in a rat model
NR2A-and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Gilmartin MR, et al.
Learning & Memory, 20(6), 290-294 (2013)
Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor
Ghersi MS, et al.
Psychopharmacology, 232(10), 1843-1857 (2015)