S1141
Spermine tetrahydrochloride
BioReagent, Molecular Biology
Sinónimos:
N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
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Fórmula empírica (notación de Hill):
C10H26N4 · 4HCl
Número CAS:
Peso molecular:
348.18
UNSPSC Code:
12352116
NACRES:
NA.52
PubChem Substance ID:
EC Number:
206-189-8
Beilstein/REAXYS Number:
3911771
MDL number:
Form:
solid
Quality level:
Servicio técnico
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Molecular Biology
Quality Level
product line
BioReagent
form
solid
mp
310-311 °C (dec.) (lit.)
solubility
H2O: soluble 100 mg/mL, clear, colorless to light yellow
foreign activity
DNase, RNase, protease, NICKase, none detected
storage temp.
room temp
SMILES string
Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
InChI
1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
General description
Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.
Application
Used to precipitate DNA from low salt aqueous buffers.
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Contenido relacionado
Instructions
Davis, L., et al.
Basic Methods in Molecular Biology, 120-120 (1986)
D C Allison et al.
Annals of surgery, 214(6), 648-656 (1991-12-01)
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Aracely A Lutes et al.
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