S3132
Seleno-L-methionine
≥98% (TLC), powder, IgE expression inhibitor
Sinónimos:
(S)-2-Amino-4-(methylseleno)butyric acid
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Acerca de este artículo
Fórmula lineal:
CH3SeCH2CH2CH(NH2)CO2H
Número CAS:
Peso molecular:
196.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleServicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleNombre del producto
Seleno-L-methionine, ≥98% (TLC), powder
SMILES string
C[Se]CC[C@H](N)C(O)=O
InChI
1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI key
RJFAYQIBOAGBLC-BYPYZUCNSA-N
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Quality Level
¿Está buscando productos similares? Visita Guía de comparación de productos
Categorías relacionadas
Application
Seleno-L-methionine has been used:
- in toxicity studies in Japanese Medaka embryos
- to study its effects on selenium status indicators in pregnant long-tailed macaques (Macaca Fascicularis)
- to label proteins for single wavelength anomalous dispersion (SAD) phasing
Seleno-L-methionine has been used:
- as a nonchemical stressor to treat Japanese Medaka fish embryos
- to label proteins for Single wavelength Anomalous Dispersion (SAD) phasing
- to study the distribution and inhibition effects of seleno-L-methionine on 4T1 mouse mammary carcinoma
Biochem/physiol Actions
Seleno-L-Methionine (SeMet) is capable of repressing atopic dermatitis (AD)-like skin lesions. It can also prevent the expression of total immunoglobulin E (IgE) and interleukin 4 (IL-4). It can cause ecotoxicity as it is absorbed by fish through diet.
Seleno-L-methionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. Seleno-L-methionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by selenomethionine in the micromolar range (45 to 130μM), while growth inhibition of normal fibroblasts required 1mM selenomethionine.
General description
Seleno-L-Methionine (SeMet), an organic form of selenium is found in Cupriavidus metallidurans.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
Clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
250.3 - 346.3 °F
flash_point_c
121.3 - 174.6 °C
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Seleno-L-methionine is the predominant organic form of selenium in Cupriavidus metallidurans CH34 exposed to selenite or selenate
Avoscan L, et al.
Applied and Environmental Microbiology, 72(9), 6414-6416 (2006)
Arka Chakraborty et al.
Nucleic acids research, 45(2), 951-967 (2016-12-03)
The mitochondrial genome (mtDNA) is assembled into nucleo-protein structures termed nucleoids and maintained differently compared to nuclear DNA, the involved molecular basis remaining poorly understood. In yeast (Saccharomyces cerevisiae), mtDNA is a ∼80 kbp linear molecule and Abf2p, a double
H Sies et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 53(3-4), 228-232 (1998-06-10)
Cellular defense against excessive peroxynitrite generation is required to protect against DNA strand-breaks and mutations and against interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine. We recently demonstrated a role of selenium-containing enzymes catalyzing
A protocol to retain weakly interacting protein complexes for structural studies using an appropriate linker
Chichili VPR, et al.
Protocol Exchange (2013)
Distribution and inhibition effect of Seleno-L-Methionine on 4T1 mouse mammary carcinoma.
Song H
International Journal of Physiology, Pathophysiology and Pharmacology, 7(2), 76-86 (2015)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico