SAB2900695
Anti-ADCYAP1R1 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
ADCYAP1R1, PAC1, PAC1-R, PACAP receptor 1, Pac1 receptor, Pac1 receptors
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Acerca de este artículo
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC
Citations:
2
Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
dog, human, Xenopus, chicken, monkey
technique(s)
immunohistochemistry: 15 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADCYAP1R1(117)
General description
Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein is a member of the class B G-protein-coupled receptors (GPCRs). It is expressed ubiquitously in the central nervous system (CNS) and peripheral tissues. It has an N-terminal extracellular domain (ECD) and a transmembrane domain (TMD). ADCYAP1R1 gene is located on human chromosome 7p14.
Immunogen
Synthetic 17 amino acid peptide from C-terminus of human ADCYAP1R1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog, Bat, Chicken, Lizard, Xenopus (100%); Stickleback, Pufferfish, Zebrafish (94%); Mouse, Rat, Hamster, Elephant, Bovine, Horse, Pig (88%).
Biochem/physiol Actions
Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein can activate the adenylyl cyclase stimulatory G protein Gs. It regulates circadian rhythm, food intake, and the immune system. PAC1R plays a vital role in glucose metabolism, learning and memory, neuronal ontogenesis, and apoptosis. ADCYAP1R1 is identified as a potential drug target for mental disorders and dry eye syndrome.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Supplied at 1 mg/ml
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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flash_point_f
Not applicable
flash_point_c
Not applicable
wgk
nwg
Clase de almacenamiento
12 - Non Combustible Liquids
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Kazuhiro Kobayashi et al.
Nature structural & molecular biology, 27(3), 274-280 (2020-03-12)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide hormone. The PACAP receptor PAC1R, which belongs to the class B G-protein-coupled receptors (GPCRs), is a drug target for mental disorders and dry eye syndrome. Here, we present a cryo-EM structure
M Stoffel et al.
Genomics, 23(3), 697-699 (1994-10-01)
The gene encoding the human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R1) was mapped to chromosome 7 by PCR analysis of genomic DNA from a human/rodent somatic cell hybrid mapping panel. This assignment was confirmed and the gene