SAB4500797
Anti-AKT antibody produced in rabbit
affinity isolated antibody
Sinónimos:
AKT, AKT1 kinase, C-AKT, PKB, kinase Akt1
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Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
33
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Permítanos ayudarlebiological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AKT1(207)
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General description
Anti-AKT Antibody detects endogenous levels of total AKT protein.
AKT serine/threonine kinase 1 (AKT1), also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB-α), is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of the AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
AKT serine/threonine kinase 1 (AKT1), also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB-α), is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of the AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human Akt.
Immunogen Range: 90-139
Immunogen Range: 90-139
Application
Anti-AKT antibody produced in rabbit has been used in Western Blotting.
Biochem/physiol Actions
AKT serine/threonine kinase 1 (AKT1) acts as a regulator of cell-survival and anti-apoptotic functions. This protein has a crucial role in tumorigenesis. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in AKT1 signaling leads to the development of schizophrenia.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer
Hongfang Li
OncoTargets and Therapy (2017)
AKT plays a central role in tumorigenesis
Joseph R
Proceedings of the National Academy of Sciences of the USA (2001)
AKT plays a central role in tumorigenesis
Effat S
Nature Genetics (2004)
Xin-Tong Fan et al.
Frontiers in endocrinology, 9, 633-633 (2018-11-09)
Studies of nesfatin-1 in glucose metabolism have become a topic of interest recently, however, the specific receptor for nesfatin-1 has not yet been identified. Some studies hinted at a connection between nesfatin-1 and the ghrelin receptor, growth hormone secretagogue receptor.
Akt1/PKBa Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice*
Han Cho
The Journal of Biological Chemistry (2001)
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