SML0059
BLT-1
≥98% (HPLC)
Sinónimos:
2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53
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Fórmula empírica (notación de Hill):
C12H23N3S
Número CAS:
Peso molecular:
241.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
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Permítanos ayudarleInChI
1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
SMILES string
CCCCCCC1CCC\C1=N/NC(N)=S
InChI key
OWGUSBISUVLUJF-SDNWHVSQSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥13 mg/mL
storage temp.
2-8°C
Quality Level
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Application
BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.
BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1.
Biochem/physiol Actions
Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.
Specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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