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Merck

T1500

Testosterone

≥98%

Sinónimos:

17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone

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About This Item

Fórmula empírica (notación de Hill):
C19H28O2
Número CAS:
58-22-0
Peso molecular:
288.42
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
24899970
EC Number:
200-370-5
Beilstein/REAXYS Number:
1915399
MDL number:
MFCD00003654

Nombre del producto

Testosterone, ≥98%

InChI key

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥98%

form

powder

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml
absolute ethanol: soluble 0.5 mg/ml
chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow
H2O: insoluble
dioxane: soluble
methanol: soluble
methyl oleate: slightly soluble
vegetable oils: soluble

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... AR(367), EBP(10682), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)

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Biochem/physiol Actions

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Application

Testosterone has been used as a standard to study the developmental profile of steroid hormones in male and female rat brains. This hormone has also been used to evaluate its effects on muscle mass and signaling in mice.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Testosterone dissolves in chloroform at 100 mg/ml to yield a clear, colorless to very faint yellow solution. It is also soluble in methanol, absolute ethanol (0.5 mg/ml), 45 percent (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin (18.2 mg/ml), vegetable oils and dioxane. It is slightly soluble in methyl oleate and insoluble in water.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000486696
0000486696
0000333985
0000333985
0000452489

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the method of production for Product T1500, Testosterone?

    This information is listed on the product's Certificate of Origin, which is lot-specific and, thus, subject to change. Enter the lot number of interest into the Certificate of Origin search box on the product page to find this information.

  6. How long can I store a solution of Product T1500, Testosterone?

    We have not determined the solution stability of this product. As a guideline, please note the stability of product no. T5411, Testosterone solution 1.0 mg/mL, which is stable for  3 years at 2-8 C.

  7. What can I use to prepare a solution of Product T1500, Testosterone?

    The product is soluble in absolute ethanol (0.5 mg/ml), It is also soluble in vegetable oils, soluble in dioxan and slightly soluble in methyl oleate.

  8. It is possible to sterile filter a solution of Product T1500, Testosterone?

    A solution of testosterone cannot be sterile filtered, since the compound will stick to the filter paper, according to Sigma cell culture scientists' experience.

  9. How could I dissolve Product T1500, Testosterone for cell culture use?

    This product has not been tested for cell culture use. We offered Testosterone for cell culture, now discontinued, and for it our 1998 Sigma Cell Culture advised to dissolve 1 mg in 2.0 mL absolute ethanol, gently swirl to dissolve, then add 48 mL sterile medium to prepare 20 ug/ml stock solution. Working range: 20-300 ng/ml.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Chikwendu Ibebunjo et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E327-E340 (2010-11-04)
Declines in skeletal muscle size and strength, often seen with chronic wasting diseases, prolonged or high-dose glucocorticoid therapy, and the natural aging process in mammals, are usually associated with reduced physical activity and testosterone levels. However, it is not clear
Anne T M Konkle et al.
Endocrinology, 152(1), 223-235 (2010-11-12)
The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex
Frances S Chen et al.
Social cognitive and affective neuroscience, 10(6), 797-800 (2014-09-07)
Physical size and strength are associated with dominance and threat. The current study tested (i) whether men's evaluations of male strangers would be negatively influenced by cues indicating physical formidability, and (ii) whether these evaluations would be influenced by oxytocin
Jianzhen Li et al.
Biology of reproduction, 100(2), 468-478 (2018-11-13)
The role of androgenic steroids on ovarian development has attracted much attention in recent years, but the molecular mechanism is still largely unknown. In this study, using zebrafish as a model, we found that the trace metal zinc mediates the
James R Bell et al.
American journal of physiology. Heart and circulatory physiology, 306(9), H1265-H1274 (2014-03-13)
Estrogen in females is conventionally considered a cardioprotective influence, but a role for estrogen in male cardioprotection has yet to be defined. Estrogen biosynthesis from testosterone is regulated by aromatase. Aromatase has recently been shown to be expressed in the
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