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Merck

T3516

Thioflavin T

Powder

Sinónimos:

Basic Yellow 1, Thioflavine T

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About This Item

Fórmula empírica (notación de Hill):
C17H19ClN2S
Número CAS:
2390-54-7
Peso molecular:
318.86
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24900146
EC Number:
219-228-9
MDL number:
MFCD00011944
Colour Index Number:
49005
Beilstein/REAXYS Number:
3922452

Nombre del producto

Thioflavin T, used as stain for amyloid

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

SMILES string

[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C

form

powder

composition

Dye content, ≥65%

solubility

methanol: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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Application

Thioflavin T has been used to identify the presence of amyloid fibrils in samples.

General description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
SHBS0874
SHBR5631
0000289396
0000289396
SHBQ8371

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Ritu Khurana et al.
Journal of structural biology, 151(3), 229-238 (2005-08-30)
Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles
Pai Peng et al.
Nucleic acids research, 45(2), 541-546 (2016-12-03)
We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions.
Extrinsic fluorescent dyes as tools for protein characterization.
Hawe, A., et al.
Pharmaceut. Res., 25, 1487-1499 (2008)
Matthew Biancalana et al.
Biochimica et biophysica acta, 1804(7), 1405-1412 (2010-04-20)
Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most
Tracking Aggregation and Fibrillation of Globular Proteins Using Terahertz and Far-Infrared Spectroscopies
Gretel Png
Taiwan yi Xue Hui za Zhi. Journal of the Formosan Medical Association (2016)
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