T4661
Base Trizma®
≥99.9% (titration), crystalline
Sinónimos:
2-Amino-2-(hidroximetil)-1,3-propanodiol, Base tris, THAM, Tris(hidroximetil)-aminometano, Trometamol
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Fórmula lineal:
NH2C(CH2OH)3
Número CAS:
Peso molecular:
121.14
UNSPSC Code:
12352104
NACRES:
NA.25
PubChem Substance ID:
EC Number:
201-064-4
Beilstein/REAXYS Number:
741883
MDL number:
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Permítanos ayudarleInChI key
LENZDBCJOHFCAS-UHFFFAOYSA-N
InChI
1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
SMILES string
NC(CO)(CO)CO
description
aminopeptidase substrate
assay
≥99.9% (titration)
form
crystalline
loss
≤5% (loss on drying, 110 °C)
color
white
pH
10.0-11.5
useful pH range
7-9
pKa (25 °C)
8.1
bp
219-220 °C/10 mmHg (lit.)
mp
167-172 °C (lit.)
solubility
water: soluble (400 g plus 600 mL of water)
λ
(290nm < 0.05), in 5 mM Tris; DNA (40% (w/w))
application(s)
diagnostic assay manufacturing
Quality Level
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General description
Tris is an established basimetric standard and buffer used in biochemistry and molecular biology. It may be used by itself as a buffer or as a component of mixed buffer formulations, such as Tris-EDTA (TE) buffer, Tris-acetate-EDTA (TAE) buffer, Tris-borate-EDTA (TBE) buffer, etc. It is pure, essentially stable, relatively non-hygroscopic and has a high equivalent weight.
Application
Tris base has been used:
- As a component of lysis buffer for cell disruption
- In the preparation of TBE solution for PAGE (polyacrylamide gel electrophoresis)
- In studies of double stranded complexes of peptide nucleic acids (PNA) and their complementary DNA sequences, by use of anion exchange HPLC
- In capillary electrochromatography and UV analysis of tocopherols and tocotrienols
Features and Benefits
Features:
- Qualified Raw Materials: Products that meet the stringent requirements of the Elevated Assurance Program, ensuring compliance with regulatory standards.
- Comprehensive Documentation: Includes essential documents such as certificates, impurity profiles, and declarations to support audits and risk assessments.
- M-Clarity™ Quality Attributes: Products are classified within the MQ300 quality segment or higher, demonstrating superior quality assurance. M-Clarity™ Program
- Confirmed Process Controls: Established processes that ensure consistency and reliability in manufacturing.
- Enhanced Change Notification: Timely updates on any changes to product specifications or processes, ensuring transparency and compliance.
- Freely Available Dossiers: Access to robust, ready-to-present product dossiers that include:
- Site quality assessment
- ISO 9001 certificate
- Detailed product specifications
- Relevant declarations/statements (e.g., animal origin content, BSE/TSE, nitrosamine)
- Regulatory Compliance: Helps you meet compliance standards effectively, reducing the risk of regulatory issues.
- Audit Readiness: Instills confidence during audits with comprehensive documentation and confirmed process controls, demonstrating your commitment to high-quality products.
- Operational Transparency: Supports supply chain transparency, allowing you to track and verify the quality of raw materials.
- Enhanced Support: Provides exceptional quality-related information and tailored assistance to meet your specific needs.
- Risk Mitigation: Facilitates thorough risk assessments with detailed documentation, helping you manage potential compliance challenges.
- Informed Decision-Making: Access to clear and comprehensive product information enables better decision-making and enhances operational efficiency.
Packaging
Meets all specifications for T1503. For biotechnology, diagnostics or manufacturing use. Please inquire for commercial quantities.
Analysis Note
Not pyrogen tested. Certificates of analysis are available with lot specific information.
Other Notes
Los valores de pH de todas las disoluciones tampón son dependientes de la temperatura y la concentración. Para los tampones Tris, el pH aumenta alrededor de 0,03 unidades por °C de disminución de la temperatura, y disminuye 0,03-0,05 unidades al ser diluido por 10.
Para aplicaciones precisas, debe utilizarse un peachímetro cuidadosamente calibrado con un electrodo de vidrio/calomelano combinados.
Para aplicaciones precisas, debe utilizarse un peachímetro cuidadosamente calibrado con un electrodo de vidrio/calomelano combinados.
Legal Information
M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany
Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Enzymatic Activity Assays for Base Excision Repair Enzymes in Cell Extracts from Vertebrate Cells.
Caglayan M, et al.
Bio-protocol, 5(11) (2015)
Accumulated lipids rather than the rigid cell walls impede the extraction of genetic materials for effective colony PCRs in Chlorella vulgaris.
Tear CJY, et al.
Microbial cell factories, 12(1), 106-106 (2013)
Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq
Ding J, et al.
Nature Protocols, 10(9), 1433-1433 (2015)
Recognition and strand displacement of DNA oligonucleotides by peptide nucleic acids (PNAs). High-performance ionexchange chromatographic analysis
Lesignoli F, et al.
Journal of Chromatography A, 922(1-2), 177-185 (2001)
Capillary electrochromatographic evaluation of vitamin active oil constituents: tocopherols and tocotrienols.
Abidi SL and Rennick KA
Journal of Chromatography A, 913(1-2), 379-386 (2001)
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