T6397

3,3′,5-Triiodo-L-thyronine sodium salt

Name: 3,3′,5-Triiodo-<SC>L</SC>-thyronine sodium salt
Brand: SIGMA

powder, BioReagent, suitable for cell culture

Sinónimos:

Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃

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About This Item

Fórmula empírica (notación de Hill):

C₁₅H₁₁I₃NNaO₄

Número CAS:

55-06-1

Peso molecular:

672.96

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24900372

EC Number:

200-223-5

Beilstein/REAXYS Number:

8179867

MDL number:

MFCD00002594

biological source:

synthetic

form:

powder

assay:

≥95%

Nombre del producto

3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

biological source

synthetic

product line

BioReagent

assay

≥95%

form

powder

potency

0.02-50 ng/mL (lit.)

technique(s)

cell culture | mammalian: suitable

solubility

ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

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Categorías relacionadas

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Hormones

Molecular Biology & Functional Genomics

Physical form

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Preparation Note

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T₃) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T₃ regulates cell differentiation and protein expression. The interaction of T₃ with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T₃ hormone is reduced in hypothyroidism.

General description

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Visite la Librería de documentos

Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)

Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha

Neumann H, et al.

The Journal of Experimental Medicine, 185(2), 305-316 (1997)

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

Sussman MA, et al.

The Journal of Clinical Investigation, 105(7), 875-886 (2000)

Medical Biochemistry, 769-769 (2001)

Hormones Growth Factors & Oncogenes, 219-219 (1987)

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