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Webinar

 
Webinar: Hot Melt Extrusion with Polyvinyl Alcohol
 

Hot Melt Extrusion with Polyvinyl Alcohol: Overcoming Challenges in API Solubility and Bioavailability

Thursday, March 2, 2017

Session 1: 9:00 AM CET, 12:00 AM PST,  
3:00 AM EST

Duration: 1 Hour
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Session 2: 5:00 PM CET, 8:00 AM PST,
11:00 AM EST

Duration: 1 Hour
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Abstract:
This webinar will discuss how to overcome challenges in API solubility and bioavailability by using polyvinyl alcohol as a matrix polymer in hot melt extrusion.

Poor solubility of active pharmaceutical ingredients (APIs) is a critical challenge in oral solid drug development. It is estimated that up to 90 % of drugs in the pharmaceutical pipeline are poorly soluble. For these APIs, an advanced formulation that increases solubility can be the key factor in bringing the drug to market.

One formulation technology to increase solubility and, consequently, improve bioavailability of drugs is hot melt extrusion (HME). It is a solvent-free process that is applicable to a broad range of APIs. With this technology, the API is dispersed, often down to the molecular level, into a polymer matrix to form an amorphous solid dispersion or solid solution. Polyvinyl alcohol (PVA) is a well-established pharmaceutical excipient that provides special functionalities as a new HME matrix polymer.

This webinar will discuss the basic challenges of HME in solubility enhancement combined with stable, high drug loads. Case studies will include data addressing a variety of parameters from extrusion to final formulation, such as API application range, stability of extrudates, and release kinetics.

In this webinar you will learn:
  • Fundamentals of hot melt extrusion for pharmaceuticals
  • Application of PVA to increase API solubility, achieve stable, high drug loads, and expand the application range of HME
  • How to modify the release kinetics in subsequent drug formulations
Presenter:
Ranjeet Patil, Technology Manager
Speaker: Sessions 1 and 2

Dr. Finn Bauer is Director for Solid Formulations R&D, recently launching two excipients for sustained release and solubility enhancement through hot melt extrusion. He is a biochemist by education and holds a Doctoral degree from the University of Bayreuth, Germany.

With broad experience in managing product and application development projects, Finn has guided many programs in his 10-year career within our company, covering positions from Quality Control and Project Management to R&D and Site Manager in our US subsidiary.


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