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MABS1196 Anti-SENP1 Antibody, clone 8B6.1

Anti-SENP1 Antibody, clone 8B6.1 is an antibody against SENP1 for use in Western Blotting.

Anti-SENP1 Antibody, clone 8B6.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: General Post-translation Modification Gene Symbol: SENP1 UniProt Number: Q9P0U3
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MABS1196
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMABS1196
      DescriptionAnti-SENP1 Antibody, clone 8B6.1
      Alternate Names
      • Sentrin-specific protease 1
      • Sentrin/SUMO-specific protease SENP1
      Background InformationSentrin-specific protease 1 (EC 3.4.22.68; UniProt Q9P0U3; also known as Sentrin/SUMO-specific protease SENP1) is encoded by the SENP1 gene (Gene ID 29843) in human. SUMOylation, protein posttranslation modification by small ubiquitin-like modifier (SUMO), is a signaling event in many cellular processes. As is the case with ubiquitination, SUMOylation is a reversible process. SUMO E1 activating enzyme, E2 conjugating enzyme, and E3 ligase mediate SUMOylation of substrate proteins, while a family of SUMO-specific proteases (SENPs) are responsible for the deSUMOylation. Seven SENPs are identified in human (SENP1-3 and SENP5-8). SENP1 processes full-length SUMO1, SUMO2 and SUMO3 to their mature forms and mediates their removal (deconjugation) from substrate proteins, including BHLHE40/DEC1, CCAR2, CLOCK, DBC1, HADC1, HIPK2, MTA1, p53, and SIRT1. SENP1 is reported to be overexpressed and induced by IL-6 in multiple myeloma (MM) cells, and SENP1-knockdown triggers apoptosis and reduces viability, proliferation and colony forming ability of MM cells.
      References
      Product Information
      FormatCulture Supernatant
      PresentationMouse monoclonal IgG2bλ hybridoma culture supernatant with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SENP1 Antibody, clone 8B6.1 is an antibody against SENP1 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant fragment from the C-terminal half of human SENP1.
      EpitopeInternal (C-terminal half).
      Clone8B6.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms of human SENP1 reported by UniProt (Q9P0U3).
      IsotypeIgG2bλ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SENP1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~73 kDa observed. 73.48 kDa (isoform 1), 73.35 kDa (isoform 2) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: A 1:2,000 dilution of this antibody detected SENP1 in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1196 04055977335255