Optimization and Scale-Up of Tangential
Flow Filtration Applications
Two-Day Course
Course Description
This two-day course examines the in-depth theory of tangential flow filtration (TFF) as well as the latest techniques to develop an efficient and effective TFF process. During a practical laboratory session, you will determine optimal operating conditions using a model feed stream in a laboratory system to perform concentration and cleaning steps. Then, through a real-life case study, you will scale-up and size a TFF process with specific product purity objectives.
Course ID: TRTFF03
Dates & Venue
Sep 15–16, 2020
Molsheim, France
M Lab™ Collaboration Center
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Sep 17–18, 2020
Shanghai, China
M Lab™ Collaboration Center
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Sep 23–24, 2020
São Paulo, Brazil
M Lab™ Collaboration Center
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Oct 6–8, 2020
Livestream, Global
M Lab™ Collaboration Center
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Nov 17–18, 2020
Molsheim, France
M Lab™ Collaboration Center
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Course Content
- Rapid development of a high performance TFF process
- Understanding process scale-up options
- Assurance of optimum TFF process parameters
- Process issues
- Meeting your product purity and quality targets
Learning Goals
- Identify and define TFF operating parameters
- Develop methodology for selection of critical TFF parameters
- Develop methodology for operation of TFF processes including concentration and diafiltration
- Operate a screening and optimization protocol
- Apply the scale-up methodology for TFF processes.
Who should attend?
- This course is designed for Research & Development scientists and engineers who are responsible for developing and implementing production-scale TFF processes. Participants must have completed the “Introduction to tangential flow filtration principles and operation” course or have equivalent experience.
What will you receive?
- A copy of the course materials.
- Protocol and results of laboratory sessions
- The solution from the workshop, showing the design of a production-scale TFF process
- A certificate of attendance
Course Schedule and Program
Day 1: 08.30 – 18.15
- Welcome and course introduction
- Tangential flow filtration refresher
- Selection of critical TFF parameters
- Practical session – flux excursion
- Workshop – optimum TMP determination
- Operation of TFF processes - concentration
- Practical session - product concentration
Day 2: 08.30 – 17.00
- Operation of TFF processes - diafiltration
- Workshop - product concentration data analysis
- Practical session - diafiltration optimization
- Workshop – optimum diafiltration determination
- Establish scale-up methodology for TFF processes
- Workshop – scale-up case study
- Final assessment and course wrap-up
Enrollment Limited to 10 Participants
Due to the hands-on nature of this course, enrollment is limited to 10. We recommend early booking to ensure a place.
Price
Please contact your local representative or email ilearn@merckgroup.com for a quote.