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ABE91 Anti-JMJD8 Antibody

Anti-JMJD8 Antibody is a Rabbit Polyclonal Antibody for detection of JMJD8 also known as Jumonji domain-containing protein 8 & has been validated in WB.

Anti-JMJD8 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histone Modifying Proteins Gene Symbol: JMJD8, C16orf20, PP14397 UniProt Number: Q96S16
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ABE91
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Po, Chp, Rhesus Macaque, Ca, EqWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE91
      DescriptionAnti-JMJD8 Antibody
      Alternate Names
      • JMJD
      • JmjC domain-containing protein 8
      • Jumonji domain-containing protein 8
      Background InformationCovalent modification of histones plays critical role in regulating chromatin structure and transcription. JMJD8 is one member of the family of JmjC domain-containing histone demethylation (JHDM) enzymes. These proteins remove specific methyl marks from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. While two isoforms of JMJD8 have been described, further study is still required to clarify the roles and mechanisms of JMJD8 among other JHDM protein family members.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa nuclear extract
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-JMJD8 Antibody is a Rabbit Polyclonal Antibody for detection of JMJD8 also known as Jumonji domain-containing protein 8 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human JMJD8.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Pig
      • Chimpanzee
      • Rhesus Macaque
      • Canine
      • Horse
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Porcine, Chimpanzee, Rhesus Macaque, Canine, and Equine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • JMJD8
      • C16orf20
      • PP14397
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~37 kDa observed. Two isoforms with molecular weights of ~34 kDa and ~37 kDa have been described. An uncharacterized band at ~160 kDa may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa nuclear extract.

      Western Blot Analysis: 1 mg/mL of this antibody dected JMJD8 in 10 mg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE91 04053252754975