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565730 Scriptaid - CAS 287383-59-9 - Calbiochem

A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.

Scriptaid - CAS 287383-59-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII

Primary Target: HDAC
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      287383-59-9C₁₈H₁₈N₂O₄
      Description
      OverviewA relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 µg/ml (6-8 µM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.
      Catalogue Number565730
      Brand Family Calbiochem®
      Synonyms6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII
      References
      ReferencesWon, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 11328.
      Su, G.H., et al. 2000. Cancer Res. 60, 3137.
      Product Information
      CAS number287383-59-9
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,544,957.
      FormOff-white Solid
      Hill FormulaC₁₈H₁₈N₂O₄
      Chemical formulaC₁₈H₁₈N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHDAC
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565730 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Scriptaid - CAS 287383-59-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Scriptaid - CAS 287383-59-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      565730

      References

      Reference overview
      Won, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 11328.
      Su, G.H., et al. 2000. Cancer Res. 60, 3137.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII
      DescriptionA relatively non-toxic hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient reporter assays in a concentration-dependent manner. Useful agent for transfection assays in reporter systems due to the lack of interference with the ability of reporter construct to measure positive activation of transcription factor in response to signal transduction stimulus. It causes over 100-fold increase in histone acetylation in PANC-1 cells at 2 µg/ml (6 µM). Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.
      FormOff-white Solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number287383-59-9
      Chemical formulaC₁₈H₁₈N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (4 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWon, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 11328.
      Su, G.H., et al. 2000. Cancer Res. 60, 3137.