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575307 T113242 - CAS 195533-44-9 - Calbiochem

A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin.

T113242 - CAS 195533-44-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: T1, (4-N,Nʹ-Dimethylanilino)-pentafluorosulfonamide

Primary Target: β-tubulin
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      195533-44-9C₁₄H₁₁F₅N₂O₂S
      Description
      OverviewA cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcriptions has been shown to be mediated by Erk signalling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).
      Catalogue Number575307
      Brand Family Calbiochem®
      SynonymsT1, (4-N,Nʹ-Dimethylanilino)-pentafluorosulfonamide
      References
      ReferencesZiegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 458.
      Ziegelbauer, J., et al. 2001. Mol. Cell 8, 339.
      Product Information
      CAS number195533-44-9
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₄H₁₁F₅N₂O₂S
      Chemical formulaC₁₄H₁₁F₅N₂O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetβ-tubulin
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      575307 0

      Documentation

      T113242 - CAS 195533-44-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      T113242 - CAS 195533-44-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      575307

      References

      Reference overview
      Ziegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 458.
      Ziegelbauer, J., et al. 2001. Mol. Cell 8, 339.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-October-2010 RFH
      SynonymsT1, (4-N,Nʹ-Dimethylanilino)-pentafluorosulfonamide
      DescriptionA cell-permeable pentafluorosulfonamide compound that covalently binds to β-tubulin and induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcription has been shown to be mediated by the Erk signaling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number195533-44-9
      Chemical formulaC₁₄H₁₁F₅N₂O₂S
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesZiegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 458.
      Ziegelbauer, J., et al. 2001. Mol. Cell 8, 339.