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852046 Fmoc-Ser(Trt)-OH

Fmoc-Ser(Trt)-OH Novabiochem®. CAS 111061-56-4, molar mass 569.65 g/mol.

Fmoc-Ser(Trt)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 111061-56-4 Molar Mass: 569.6 g/mol Hill Formula: C₃₇H₃₁NO₅
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
111061-56-4C₃₇H₃₁NO₅569.6 g/mol
Description
Catalogue Number852046
Replaces04-12-1092
Brand Family Novabiochem®
Alternate Names
  • N-α-Fmoc-O-trityl-L-serine
Background InformationThe side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS [1, 2] or 20% dichloroacetic acid in DCM [3], enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphoserine containing peptides and peptides modified at the serine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2, 4].

The product number for this product was previously 04-12-1092.

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References
Product Information
CAS number111061-56-4
Hill FormulaC₃₇H₃₁NO₅
Molar Mass569.6 g/mol
HS Code2924 29 99
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationFmoc-Ser(Trt)-OH Novabiochem®. CAS 111061-56-4, molar mass 569.65 g/mol.
Biological Information
Physicochemical Information
Melting Point200 °C
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at -15°C to -25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Purity (TLC(157A))≥ 98 %
Purity (TLC(0811))≥ 98 %
Enantiomeric purity≥ 99.5 % (a/a)
Assay (HPLC, area%)≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)clearly soluble
Assay (acidimetric)≥ 95.0 %
Water (K. F.)≤ 2.0 %
For TLC-Systems see our General Catalog

Documentation

Fmoc-Ser(Trt)-OH SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] K. Barlos, et al. (1991) Tetrahedron Lett., 32, 471.
  • [2] K. Barlos, et al. (1998) J. Peptide Res., 51, 194.
  • [3] M. P. Coba, et al. (2003) J. Peptide Res., 61, 17.
  • [4] X.-H. Tong, et al. in 'Peptide Revolution: Genomics, Proteomics & Therapeutics, , Proc. 18th American Peptide Symposium', M. Chrev & T. K. Sawyer (Eds), Cardiff, American Peptide Society, 2003, pp. 21.