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AB15614-50UL Anti-CNGA3 Antibody

Anti-CNGA3 Antibody detects level of CNGA3 & has been published & validated for use in IH & WB.

Anti-CNGA3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: CNGA3, CNCG3, CCNCalpha, CNG3, CCNCa, ACHM2, CCNC1, CNG-3 UniProt Number: Q16281
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AB15614-50UL
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15614-50UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CNGA3 Antibody
      Alternate Names
      • Cyclic nucleotide-gated channel
      • CNG3
      References
      Product Information
      FormatAffinity Purified
      Control
      • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationLyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-CNGA3 Antibody detects level of CNGA3 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat brain membrane lysate.
      Immunohistochemistry on frozen rat brain sections.
      Dilutions should be made using a carrier protein such as BSA (1-3%).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified peptide from the C-terminus of rat CNGA3 (Accession number Q9QWN7).
      HostRabbit
      SpecificityRecognizes CNGA3 (Cyclic nucleotide-gated channel, CNG3).
      Species Reactivity
      • Rat
      Species Reactivity NoteThe immunogen sequence is 15 of 18 amino acids identical in mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described.
      Gene Symbol
      • CNGA3
      • CNCG3
      • CCNCalpha
      • CNG3
      • CCNCa
      • ACHM2
      • CCNC1
      • CNG-3
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16281 # Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
      SIZE: 694 amino acids; 78838 Da
      SUBUNIT: Heterooligomeric complex with CNGB3.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Prominently expressed in retina.
      DISEASE: SwissProt: Q16281 # Defects in CNGA3 are a cause of achromatopsia type 2 (ACHM2) [MIM:216900]; also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night.
      SIMILARITY: SwissProt: Q16281 ## Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. & Contains 1 cyclic nucleotide-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB15614-50UL 04053252590665

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies