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AB5250-200UL Anti-Potassium Channel TASK1 Antibody

Anti-Potassium Channel TASK1 Antibody detects level of Potassium Channel TASK1 & has been published & validated for use in IH & WB.

Anti-Potassium Channel TASK1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNK3, KT3.1, K2p3.1, TASK-1, TASK1, OAT1, TBAK1 UniProt Number: O14649
AB5250-200UL
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5250-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Potassium Channel TASK1 Antibody
      Alternate Names
      • TWIK-Related Acid Sensitive
      • TASK-1
      • cTBAK
      • Kcnk3
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-Potassium Channel TASK1 Antibody detects level of Potassium Channel TASK1 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat brain membranes.

      Immunohistochemistry on rat brain sections.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA purified peptide (TASK) corresponding to amino acid residues 252-269 in the cytoplasmic C-terminus of human TASK1 (Accession O14649).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThe epitope is specific for TASK1 and is not present in any other known proteins tested so far.

      SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues identical) but other species have not been tested.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq]
      Gene Symbol
      • KCNK3
      • KT3.1
      • K2p3.1
      • TASK-1
      • TASK1
      • OAT1
      • TBAK1
      UniProt Number
      UniProt SummaryFUNCTION: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
      SIZE: 43518 Da [This is the MW of the unprocessed precursor].
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
      TISSUE SPECIFICITY: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
      MISCELLANEOUS: Inhibited by external acidification. Activated by halothane and isoflurane.
      SIMILARITY: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5250-200UL 04053252735202

      Documentation

      Anti-Potassium Channel TASK1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Potassium Channel TASK1 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL - 2519182 2519182
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL - 4027353 4027353
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL - 4166595 4166595
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2557351 2557351
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2575946 2575946
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2606932 2606932
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2638913 2638913
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2325767 2325767

      References

      Reference overviewPub Med ID
      Expression of TWIK-related acid sensitive K+ channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia
      Rau, K. K., et al.
      Neuroscience, 141:955-963 (2006)  2006

      		16725275 16725275

      Data Sheet

      Title
      RABBIT ANTI-TASK-1 POTASSIUM CHANNEL AFFINITY PURIFIED POLYCLONAL ANTIBODY