Millipore Sigma Vibrant Logo

AB5580-200UL Anti-SCN8A Sodium Channel Antibody

Anti-SCN8A Sodium Channel Antibody detects level of SCN8A Sodium Channel & has been published & validated for use in IC, IH & WB.

Anti-SCN8A Sodium Channel Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SCN8A, Nav1.6, MED, NaCh6, PN4, CerIII UniProt Number: Q9UQD0
View Products on Sigmaaldrich.com
AB5580-200UL
200 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RICC, IHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5580-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-SCN8A Sodium Channel Antibody
      Alternate Names
      • Sodium Channel Nav1.6
      • NaCh6
      • PN4
      • CerIII
      Background InformationVoltage-gated sodium channels perform critical roles for electrical signaling in the nervous ssystem by generating action potentials in axons and dndrites. At least 10 genes encode sodium channels in mammals, but specific physiological roles that distinguish each of these isoforms are not well known. Nav1.6 is highly concentrated at nodes of Ranvier of both sensory and motor axons in the peripheral nervous system and at nodes in the central nervous system. Because of its consistant and restrictied labeling, Anti-Nav1.6 (AB5580) has been used effectively as a nodes of Ranvier marker.
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized peptide). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-SCN8A Sodium Channel Antibody detects level of SCN8A Sodium Channel & has been published & validated for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 3.0 μg/mL (1:200) using ECL on rat brain membranes.

      Immunohistochemistry on fixed frozen sections.

      Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPeptide corresponding to amino acids 1042-1061 from mouse (Accession number AAD20438) or rat (Accession number AAC26014) Scn8a.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Scn8a. The epitope corresponds to the intracellular loop between II and III domains of Scn8a. Does not cross react with any other known proteins.

      SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse and human due to sequence homology. Other species have not been tested.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SCN8A
      • Nav1.6
      • MED
      • NaCh6
      • PN4
      • CerIII
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UQD0 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
      SIZE: 1980 amino acids; 225280 Da
      SUBUNIT: Interacts with NEDD4 and NEDD4L (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DOMAIN: SwissProt: Q9UQD0 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
      PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis (By similarity).
      SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5580-200UL 04053252332821

      Documentation

      Anti-SCN8A Sodium Channel Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SCN8A Sodium Channel Antibody Certificates of Analysis

      TitleLot Number
      AB5580-200UL - 2276302 2276302
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2147008 2147008
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2384634 2384634
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2441898 2441898
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) - 3188705 3188705
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) - 3257101 3257101
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) - 3870067 3870067
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) - 3995738 3995738
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) - 4059943 4059943
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) - 4123366 4123366
      Show more

      Data Sheet

      Title
      RABBIT ANTI-Scn8a (Nav1.6, Type VI Sodium channel, NaCh6, PN4, CerIII) AFFINITY PURIFIED, POLYCLONAL ANTIBODY