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AB5604-50UL Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type

Detect Calcium Channel using this Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters, Signaling Neuroscience Gene Symbol: CACNA2D1, CACNA2, CACNL2A, H_DJ0560O14.1, CCHL2A, MHS3, WUGSC:H_DJ0560O14.1 UniProt Number: P54289
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AB5604-50UL
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5604-50UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type
      Alternate Names
      • Cacna2d1
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen. The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 0.75 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationDetect Calcium Channel using this Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat brain membranes.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPeptide corresponding to 15 amino acids from the rabbit alpha2 subunit (residues 27-41 of rabbit alpha2/delta-1 precursor) P13806. By sequence comparsions, the immunogen sequence used is identical in human, porcine, with mouse and rat missing only a single amino acid.
      EpitopeVoltage Gated alpha 2/delta-1, L-type
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes alpha2/delta-1 subunit, N-terminal. The epitope does not share homology with any other known proteins. Reactivity has been verified only in rat membranes.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
      Gene Symbol
      • CACNA2D1
      • CACNA2
      • CACNL2A
      • H_DJ0560O14.1
      • CCHL2A
      • MHS3
      • WUGSC:H_DJ0560O14.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P54289 # The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
      SIZE: 1091 amino acids; 123183 Da
      SUBUNIT: Dimer formed of alpha-2-1 and delta-1 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
      TISSUE SPECIFICITY: Central nervous system, skeletal muscle and aorta tissues.
      DOMAIN: SwissProt: P54289 The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity).
      PTM: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked (By similarity).
      SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta family. & Contains 1 cache domain. & Contains 1 VWFA domain.
      MISCELLANEOUS: Binds gabapentin, an antiepileptic drug.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5604-50UL 04053252626272

      Documentation

      Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CALCIUM CHANNEL, VOLTAGE GATED a2/d-1 SUBUNIT (Cacna2d1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2280278 2280278
      RABBIT ANTI-CALCIUM CHANNEL, VOLTAGE GATED α2/δ-1 SUBUNIT (Cacna2d1) - 3533049 3533049
      RABBIT ANTI-CALCIUM CHANNEL, VOLTAGE GATED α2/δ-1 SUBUNIT (Cacna2d1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 3772214
      RABBIT ANTI-CALCIUM CHANNEL, VOLTAGE GATED α2/δ-1 SUBUNIT (Cacna2d1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 3099573

      Data Sheet

      Title
      RABBIT ANTI-CALCIUM CHANNEL, VOLTAGE GATED 2/-1 SUBUNIT (Cacna2d1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies