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AB5908-200UL Anti-Potassium Channel HERG Antibody, CT

Anti-Potassium Channel HERG Antibody, C-terminus is an antibody against Potassium Channel HERG for use in IC, IP & WB.

Anti-Potassium Channel HERG Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNH2, ERG1, LQT2, erg1, HERG, SQT1, H-ERG, Kv11.1, HERG1, Erg1, ERG UniProt Number: Q12809
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AB5908-200UL
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, IP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5908-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Potassium Channel HERG Antibody, CT
      Alternate Names
      • Erg1
      • Kcnh2
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 120 μg of fusion protein (35 kD). The stock solution of the antigen can be made up using 100 μL of PBS. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. For positive control, use 20 ng of fusion protein per lane. Optimal concentrations must be determined by the end user.
      PresentationAffinity Purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-Potassium Channel HERG Antibody, C-terminus is an antibody against Potassium Channel HERG for use in IC, IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1:200-400 using ECL on HERG transfected HEK293 cells.

      Immunocytochemistry

      Immunoprecipitation

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGST fusion protein corresponding to amino acids 1106-1159 of human erg1 (HERG) (Accession number Q12809).
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes HERG (hKv11.1, Voltage gated K+ channel subfamily H member 2, KCNH2, ether-a-go-go related channel). The antibody recognizes the HERG1b splice variant but not splice variants HERG1-3 or HERG-4. The immunogen shares similiarity with rat erg2 (22/54) and rat erg3 (21/54).
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
      Gene Symbol
      • KCNH2
      • ERG1
      • LQT2
      • erg1
      • HERG
      • SQT1
      • H-ERG
      • Kv11.1
      • HERG1
      • Erg1
      • ERG
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12809 # Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
      SIZE: 1159 amino acids; 126655 Da
      SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Highly expressed in heart and brain.
      DOMAIN:SwissProt: Q12809 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
      PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
      DISEASE: SwissProt: Q12809 # Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:152427]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. & Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.
      SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain.
      Molecular Weight127 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5908-200UL 04053252278976

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-Potassium Channel HERG Antibody, CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Potassium Channel HERG Antibody, CT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HERG (hKV11.1) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2110459 2110459
      RABBIT ANTI-HERG (hKV11.1) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2384654 2384654
      RABBIT ANTI-HERG (hKV11.1) - 2560993 2560993
      RABBIT ANTI-HERG (hKV11.1) - 3896451 3896451
      RABBIT ANTI-HERG (hKV11.1) - 4146482 4146482
      RABBIT ANTI-HERG (hKV11.1) - 4265146 4265146
      RABBIT ANTI-HERG (hKV11.1) -2558353 2558353
      RABBIT ANTI-HERG (hKV11.1) -2586510 2586510
      RABBIT ANTI-HERG (hKV11.1) -2659193 2659193
      RABBIT ANTI-HERG (hKV11.1) -2688777 2688777
      Show more

      Data Sheet

      Title
      RABBIT ANTI-HERG (hKV11.1) AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies