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ABF17-I Anti-TGF-beta Receptor Antibody, type I

This rabbit polyclonal Anti-TGF-beta Receptor, type I, Cat. No. ABF17-I is tested in Flow Cytometry, Immunohistochemistry (Paraffin), and Western Blotting for the detection of TGF-beta receptor type-1.

Anti-TGF-beta Receptor Antibody, type I MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: TGFBR1, ALK5, SKR4 UniProt Number: P36897
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ABF17-I
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HFC, WB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF17-I
      ReplacesABF17
      DescriptionAnti-TGF-beta Receptor Antibody, type I
      Alternate Names
      • EC:2.7.11.30
      • TGFR-1
      • Activin A receptor type II-like protein kinase of 53kD
      • Activin receptor-like kinase 5
      • ALK-5
      • Serine/threonine-protein kinase receptor R4
      • SKR4
      • Transforming growth factor-beta receptor type I
      • TbetaR-I
      Background InformationTGF-beta receptor type-1 (UniProt: P36897; also known as EC:2.7.11.30, TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, Serine/threonine-protein kinase receptor R4, SKR4, Transforming growth factor-beta receptor type I, TbetaR-I) is encoded by the TGFBR1 (also known as ALK5, SKR4) gene (Gene ID: 7046) in human. TGF-beta R1 is found in all tissues examined and is most abundant in placenta and least abundant in brain and heart. It is also expressed in a variety of cancer cell lines. TGF-beta signaling involves its binding to the TGF-beta receptor type II (TGF-beta RII), which allows it to recruit TGF-beta receptor type I (TGF-beta RI) and assemble it as a heterodimeric receptor complex. TGF-beta RII phosphorylates TGF-beta RI in the glycine-serine (GS) rich region and activates the serine/threonine kinase activity of TGF-beta RI, which in turn phosphorylates receptor-linked Smad (Small mothers against decapentaplegic) proteins. To prevent any spontaneous phosphorylation of Smads, the inhibitor molecule FKBP12 binds to the GS region of the TGF-beta RI and blocks the access of TGF-beta RII to this domain. This inhibitory effect is removed upon TGF-beta binding to the receptor.
      References
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rabbit polyclonal Anti-TGF-beta Receptor, type I, Cat. No. ABF17-I is tested in Flow Cytometry, Immunohistochemistry (Paraffin), and Western Blotting for the detection of TGF-beta receptor type-1.
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TGF-beta receptor type-1 in human spleen, human cerebellum, human kidney, human pancreas, human placenta (chorionic villi), and human placenta (decidual cells).

      Flow Cytometry Analysis: 1 µg from a representative lot detected TGF-beta receptor type-1 in one million mouse splenocyte cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal region of human TGF-beta receptor 1.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody specifically detects TGF-beta receptor type 1 in multiple species. It targets an epitope of 15 amino acids in the C-terminal region.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse. Predicted to react with Bovine, Porcine, Rat based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TGFBR1
      • ALK5
      • SKR4
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~56 kDa observed, 55.96 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat liver tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected TGF-beta receptor type-1 in 10 µg of rat liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABF17-I 04054839178993

      Documentation

      Anti-TGF-beta Receptor Antibody, type I SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TGF-beta Receptor Antibody, type I Certificates of Analysis

      TitleLot Number
      Anti-TGF-beta Receptor, type I - 3524285 3524285
      Anti-TGF-beta Receptor, type I - 3851169 3851169
      Anti-TGF-beta Receptor, type I - 3959466 3959466
      Anti-TGF-beta Receptor, type I - 3988934 3988934
      Anti-TGF-beta Receptor, type I - 4028580 4028580
      Anti-TGF-beta Receptor, type I - 4107726 4107726
      Anti-TGF-beta Receptor, type I - 4166537 4166537
      Anti-TGF-beta Receptor, type I - 4247794 4247794
      Anti-TGF-beta Receptor, type I - 4278842 4278842
      Anti-TGF-beta Receptor, type I Polyclonal Antibody 3127631
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