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ABF29 Anti-NLRP6 (NALP6) Antibody

Anti-NLRP6 (NALP6) Antibody detects level of NLRP6 (NALP6) & has been published & validated for use in WB, IH(P).

Anti-NLRP6 (NALP6) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: NPLPR6, NALP6, PYPAF5 UniProt Number: P59044
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ABF29
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, Rhesus MacaqueWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF29
      DescriptionAnti-NLRP6 (NALP6) Antibody
      Alternate Names
      • NACHT
      • PYRIN-containing APAF1-like protein 5
      • LRR and PYD domains-containing protein 6
      Background InformationNRLP6 (NALP6) (also known as PYRIN-containing Apaf-1-like protein 5 or PYPAF5) belongs to a family of proteins that play a critical role in apoptosis and in inflammatory signaling. Its expression is highly restricted to granulocytes and T-cells. Co-expression of NALP6 with ASC results in synergistic activation of caspase-1-dependent cytokine processing, subsequent NF-kB activation, and downstream recruitment of PYPAF5 to punctate structures in the cytoplasm. Overlapping genes in NALP6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.
      References
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      Control
      • Rat basophilic leukemia (RBL) cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NLRP6 (NALP6) Antibody detects level of NLRP6 (NALP6) & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected NLRP6 (NALP6) in epithelial tissue of proximal and distal tubules of human kidney, and in human bone marrow tissue.
      Biological Information
      ImmunogenLinear peptide corresponding to NACHT domain of human NLRP6 (NALP6).
      EpitopeNACHT domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the NACHT domain of NLRP6 (NALP6).
      Species Reactivity
      • Human
      • Rat
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with Human and Rat.
      Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Mouse (93% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
      Gene Symbol
      • NPLPR6
      • NALP6
      • PYPAF5
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B.

      SUBUNIT STRUCTURE: Binds to ASC with its DAPIN domain.

      SUBCELLULAR LOCATION: Cytoplasm.

      TISSUE SPECIFICITY: Highly expressed in granulocytes. Detected at much lower levels in T-cells.
      Molecular Weight~99 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat basophilic leukemia (RBL) cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected NLRP6 (NALP6) in 10 µg of rat basophilic leukemia (RBL) cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABF29 04053252634673

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-NLRP6 (NALP6) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NLRP6 (NALP6) Antibody Certificates of Analysis

      TitleLot Number
      Anti-NLRP6 (NALP6) ANTI-NLRP6 (NALP6)
      Anti-NLRP6 (NALP6) 3046768
      Anti-NLRP6 (NALP6) - 2440202 2440202
      Anti-NLRP6 (NALP6) - 2179370 2179370
      Anti-NLRP6 (NALP6) - 3187408 3187408
      Anti-NLRP6 (NALP6) - 3206360 3206360
      Anti-NLRP6 (NALP6) - 3251481 3251481
      Anti-NLRP6 (NALP6) - 3254582 3254582
      Anti-NLRP6 (NALP6) - 3587260 3587260
      Anti-NLRP6 (NALP6) - 3762577 3762577
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