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ABN209 Anti-TTC8 Antibody

Anti-TTC8 detects levels of TTC8 proteins & has been published & validated for use in WB & IHC.

Anti-TTC8 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Cytoskeleton Gene Symbol: TTC8, BBS8 UniProt Number: Q8TAM2
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ABN209
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Pm, Eq, PorcineWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN209
      DescriptionAnti-TTC8 Antibody
      Alternate Names
      • Tetratricopeptide repeat protein 8
      • TPR repeat protein 8
      • Bardet-Biedl syndrome 8 protein
      • TTC8
      Background InformationAlso known as tetratricopeptide repeat protein 8, TTC8 is a BBSome complex that is required for ciliogenesis. It is known to associate with the Rab8 GDP/GTP exchange factor, which is localized in the basal body. Rab8(GTP) is produced and enters the primary cilium, where it promotes ciliary membrane biogenesis. Mutations in TTC8 have been identified in Bardet-Biedl syndrome (BBS), a genetic disorder which is characterized with obesity, retinal degeneration, and nephropathy.
      References
      Product Information
      FormatAffinity Purified
      Control
      • ARPE19 tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-TTC8 detects levels of TTC8 proteins & has been published & validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected TTC8 in human prostate cancer and mouse eye tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the TPR1 domain of human TTC8.
      EpitopeTPR1 domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the TPR1 domain of TTC8.
      Species Reactivity
      • Human
      • Mouse
      • Primate
      • Horse
      • Porcine
      Species Reactivity NoteDemonstrated to react with Human and Mouse. Predicted to react with Primate, Equine, and Porcine based on 100% sequence homology. Other homologies: Rat (53% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TTC8
      • BBS8
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~61 kDa observed. Uncharacterized bands at ~270 kDa, ~160 kDa, and ~38 kDa may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in ARPE19 tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected TTC8 in 10 µg of ARPE19 tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN209 04053252827860

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies