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ABN404 Anti-MCPH1 Antibody

Anti-MCPH1 Antibody is a highly specific rabbit polyclonal antibody, that targets Microcephalin & has been tested in western blotting & IHC.

Anti-MCPH1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: MCPH1 UniProt Number: Q8NEM0
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ABN404
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN404
      DescriptionAnti-MCPH1 Antibody
      Alternate Names
      • Microcephalin
      Background InformationThe protein named Microcephalin and encoded by the human gene named MCPH1 is a DNA/chromatin binding protein implicated in chromosome condensation and DNA damage induced cellular responses. MCPH1 plays a role in neurogenesis and is involved in the regulation of the size of the cerebral cortex. MCPH1 interacts with several proteins including H2AFX under DNA damage conditions and CDC27 during normal cell growth. MCPH1 is expressed cytoplasmically in a variety of cell types and tissues and is particularly expressed in the fetal brain, liver and kidney. Defects in MCPH1 can give rise to microcephaly a disease where the head circumference is markedly reduced and effected patients are mentally retarded, showing a high number of prophase-like cells in cytological examinations. In addition, cell divisions are irregular and demonstrate a delay in post-mitotic chromosome decondensation. Interestingly, recent research demonstrates that MCPH1 also functions as a tumor suppressor that is regulated by the microRNA miR-27a.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-MCPH1 Antibody is a highly specific rabbit polyclonal antibody, that targets Microcephalin & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected MCPH1 in human cerebellum, human testis, and human cerebral cortex tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human MCPH1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MCPH1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~111 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human testis tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected MCPH1 in 10 µg of human testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN404 04053252934056