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AG4000 uPA Colorimetric Substrate, ECM600, ECM610

uPA Colorimetric Substrate, ECM600, ECM610 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: All Gene Symbol: PLAU, UPA, uPA, URK, u-PA, ATF, EC 3.4.21.73 [Contains: Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B]. UniProt Number: P00749
AG4000
5 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberAG4000
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionuPA Colorimetric Substrate, ECM600, ECM610
      OverviewpyroGLU-GLY-ARG-pNA-HCL {L-Pyroglutamyl-glycyl-L-arginine-p-Nitroaniline hydrochloride

      Mol wt. 498.9

      Ex (316nm) 1.27x10(e-1)/mol/cm
      References
      Product Information
      PresentationLyophilized solid containing 45 mg D-mannitol and 5 mg substrate. Sold on the basis of substrate content.
      Quality LevelMQ100
      Applications
      Key Applications
      • Activity Assay
      Biological Information
      Purity> 95% by HPLC
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
      Gene Symbol
      • PLAU
      • UPA
      • uPA
      • URK
      • u-PA
      • ATF
      • EC 3.4.21.73 [Contains: Urokinase-type plasminogen activator long chain A
      • Urokinase-type plasminogen activator short chain A
      • Urokinase-type plasminogen activator chain B].
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00749 # Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
      SIZE: 431 amino acids; 48525 Da
      SUBUNIT: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers.
      PTM: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
      SIMILARITY: SwissProt: P00749 ## Belongs to the peptidase S1 family. & Contains 1 EGF-like domain. & Contains 1 kringle domain. & Contains 1 peptidase S1 domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C. This product is stable for 3 year as supplied

      Reconstitute with H(2)O, Following reconstitution, store at 4°C, stock solution is stable for 1-2 months at 4°C. Avoid exposure to light; material is hydroscopic
      Packaging Information
      Material Size5 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AG4000 04053252323492

      Documentation

      uPA Colorimetric Substrate, ECM600, ECM610 Certificates of Analysis

      TitleLot Number
      UROKINASE SUBSTRATE, COLORIMETRIC 3012241
      UROKINASE SUBSTRATE, COLORIMETRIC - 2121747 2121747
      UROKINASE SUBSTRATE, COLORIMETRIC - 2378772 2378772
      UROKINASE SUBSTRATE, COLORIMETRIC - 2448042 2448042
      UROKINASE SUBSTRATE, COLORIMETRIC - 2466940 2466940
      UROKINASE SUBSTRATE, COLORIMETRIC -
      UROKINASE SUBSTRATE, COLORIMETRIC - 1991266 1991266
      UROKINASE SUBSTRATE, COLORIMETRIC - 2106892 2106892
      UROKINASE SUBSTRATE, COLORIMETRIC - 2110492 2110492
      UROKINASE SUBSTRATE, COLORIMETRIC - 2303950 2303950
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      Data Sheet

      Title
      UROKINASE SUBSTRATE, COLORIMETRIC