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AG678 Connexin 43, control peptide for MAB3067

Connexin 43, control peptide for MAB3067 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Gene Symbol: GJA1, GJAL, Cx43, DFNB38, SDTY3, CX43, ODD, ODDD, ODOD, Connexin-43 UniProt Number: P17302
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AG678
100 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberAG678
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionConnexin 43, control peptide for MAB3067
      OverviewControl peptide for Chemicon Catalog Number MAB3067 (Mouse anti-connexin 43). Peptide corresponds to a 19 amino acid sequence within the C-terminal cytoplasmic domain (aa252-270) of Mouse Cx43 (2). This sequence is identical in rat and bovine. Mouse Connexin 43 is a 382 amino acid gap junction protein with a predicted M.W. of ~43 kDa.
      References
      Product Information
      PresentationSupplied as 1 mg/mL solution in PBS, pH 7.4, containing no preservatives.
      Quality LevelMQ100
      Applications
      Key Applications
      • Peptide Inhibition Assay
      Application NotesELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
      Gene Symbol
      • GJA1
      • GJAL
      • Cx43
      • DFNB38
      • SDTY3
      • CX43
      • ODD
      • ODDD
      • ODOD
      • Connexin-43
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17302 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
      SIZE: 382 amino acids; 43008 Da
      SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts with SGSM3.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
      TISSUE SPECIFICITY: Expressed in the heart and fetal cochlea.
      DISEASE: SwissProt: P17302 # Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type III and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances. & Defects in GJA1 may be the cause of syndactyly type III (SDTY3) [MIM:186100]. Syndactyly is an autosomal dominant trait and is the most common congenital anomaly of the hand or foot. It is marked by persistence of the webbing between adjacent digits, so they are more or less completely attached. In this type there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected. & Defects in GJA1 a the cause of hypoplastic left heart syndrome (HLHS) [MIM:241550]. HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.
      SIMILARITY: SwissProt: P17302 ## Belongs to the connexin family. Alpha-type (group II) subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C in undiluted aliquots. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AG678 04053252276125