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AG733 Tamm-Horsfall Glycoprotein

Tamm-Horsfall Glycoprotein MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Positive Control UniProt Number: P07911 Entrez Gene Number: NM_001008389.1, NM_003361.2
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AG733
100 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberAG733
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionTamm-Horsfall Glycoprotein
      References
      Product Information
      PresentationLyophillized from deionized water containing 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      Key Applications
      • Positive Control
      Biological Information
      Purity>95%.
      SourceHuman urine, tested negative for and HIV I/II and HCV antibodies and HBsAg.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
      Gene Symbol
      • UMOD
      • THP
      • THGP
      • HNFJ
      • ADMCKD2
      • uromucoid
      • uromodulin
      • MCKD2
      • FJHN
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07911 # Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
      SIZE: 640 amino acids; 69761 Da
      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage in the urine.
      TISSUE SPECIFICITY: Synthesized by the kidneys and is the most abundant protein in normal human urine.
      DISEASE: SwissProt: P07911 # Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy (HNFJ) [MIM:162000]. HNFJ is a heritable autosomal dominant renal disease characterized by juvenil onset of hyperuricaemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis. & Defects in UMOD are the cause of medullary cystic kidney disease 2 (MCKD2) [MIM:603860]. MCKD2 and HNFJ constitute a group of heritable renal diseases with a common mode of transmission (autosomal dominant) and shared features including polyuria, hyperuricaemia, progressive renal failure, and gout. Both diseases are associated with interstitial pathological changes resulting in fibrosis. While corticomedullary cysts are well documented in MCKD2, their presence in HNFJ is not well documented. The primary clinical features of MCKD2 and HNFJ vary in presence and severity, complicating the diagnosis of these conditions, particularly in milder cases. Both diseases are considered to be allelic diseases. & Defects in UMOD are a cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria [MIM:609886]. Glomerulocystic kidney disease (GCKD) and medullary cystic disease/familial juvenile hyperuricemic nephropathy (MCKD/HNFJ) are two distinct renal disorders that share some common clinical features. The former is characterized by a cystic dilatation of Bowman's space and a collapse of glomerular tuft. Familial GCKD can be associated with either hypoplastic or normal sized kidneys. A GCKD clinical variant presents the association with hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability that are reminiscent of MCKD/HNFJ.
      SIMILARITY: SwissProt: P07911 ## Contains 3 EGF-like domains. & Contains 1 ZP domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore +2-8°C for up to 3 months after date of receipt.

      DO NOT FREEZE.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AG733 04053252585388

      Documentation

      Tamm-Horsfall Glycoprotein SDS

      Title

      Safety Data Sheet (SDS) 

      Tamm-Horsfall Glycoprotein Certificates of Analysis

      TitleLot Number
      HUMAN TAMM-HORSFALL GLYCOPROTEIN PURIFIED PROTEIN - 2462711 2462711
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3261339 3261339
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3298051 3298051
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3327717 3327717
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3448873 3448873
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3717718 3717718
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3850574 3850574
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3890964 3890964
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3903771 3903771
      HUMAN TAMM-HORSFALL GLYCOPROTEIN - 3908083 3908083
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