05-909 | Anti-AP-2γ Antibody, clone 6E4/4

05-909
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-909
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-AP-2γ Antibody, clone 6E4/4
      References
      Product Information
      FormatPurified
      Applications
      ApplicationDetect AP-2γ also known as Transcription Factor AP-2 gamma with Anti-AP-2γ Antibody, clone 6E4/4 (Mouse Monoclonal Antibody), that has been demonstrated to work in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenBacterially expressed AP-2 protein
      Cloneclone 6E4/4
      HostMouse
      SpecificityAP-2γ. Reported to not cross-react with AP-2α or AP-2β.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
      Gene Symbol
      • TFAP2C
      • AP2-GAMMA
      • TFAP2G
      • hAP-2g
      • AP2-gamma
      • ERF1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q92754 # Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
      SIZE: 450 amino acids; 49177 Da
      SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I.
      SUBCELLULAR LOCATION: Nucleus (Probable).
      DOMAIN:SwissProt: Q92754 The WW-binding motif mediates interaction with WWOX.
      PTM: Sumoylated on Lys-10; which inhibits transcriptional activity.
      SIMILARITY: Belongs to the AP-2 family.
      Molecular WeightMr 50kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on nuclear extracts from HeLa cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti- AP-2g, clone 6E4/4 (mouse monoclonal IgG1) - 2054514 2054514
      Anti- AP-2gamma;, clone 6E4/4 - 30392 30392

      References

      Reference overviewApplicationPub Med ID
      The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
      Nascimento, EM; Cox, CL; MacArthur, S; Hussain, S; Trotter, M; Blanco, S; Suraj, M; Nichols, J; Kübler, B; Benitah, SA; Hendrich, B; Odom, DT; Frye, M
      Nature cell biology  13  1395-405  2011

      Show Abstract
      22101514 22101514
      Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
      Eloranta, Jyrki J and Hurst, Helen C
      J. Biol. Chem., 277: 30798-804 (2002)  2002

      Show Abstract
      Immunoblotting (Western)12072434 12072434

      Related Products & Applications

      Included Positive Control

      Catalogue Number Description  
      12-309 HeLa Nuclear Extract Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies