05-666 | Anti-BRCA2 Antibody, clone 5.23

200 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Catalogue Number05-666
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-BRCA2 Antibody, clone 5.23
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
      ApplicationDetect BRCA2 with Anti-BRCA2 Antibody, clone 5.23 (Mouse Monoclonal Antibody), that has been shown to work in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenGST fusion protein to residues 2959-3418 of human BRCA2 protein
      Cloneclone 5.23
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryInherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintainance of genome stability, specificallythe homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
      Gene Symbol
      • BRCA2
      • FACD
      • FANCB
      • FAD1
      • FAD
      • FANCD1
      • BRCC2
      • OTTHUMP00000042401
      • FANCD
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51587 # Involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation.
      SIZE: 3418 amino acids; 384225 Da
      SUBUNIT: Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoints functions. Interacts with WDR16.
      TISSUE SPECIFICITY: Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
      PTM: Phosphorylated by ATM upon irradiation-induced DNA damage.
      DISEASE: SwissProt: P51587 # Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) [MIM:600185, 114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. Mutations in BRCA2 are thought to be responsible for some inherited breast cancer. It is linked with male breast cancer. & Defects in BRCA2 are the cause of Fanconi anemia complementation group D type 1 (FANCD1) [MIM:605724]. Fanconi anemia [MIM:227650] is an autosomal recessive disorder affecting all bone marrow elements and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes.
      SIMILARITY: SwissProt: P51587 ## Contains 8 BRCA2 repeats.
      Molecular Weight390kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on in HeLa nuclear extract
      Sales RestrictionsDue to license agreement restrictions, this product cannot be purchased for resale.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C. Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-BRCA2, clone 5.23 (mouse monoclonal IgG) 2887651
      Anti-BRCA2, clone 5.23 - 22263 22263
      Anti-BRCA2, clone 5.23 - DAM1736922 DAM1736922
      Anti-BRCA2, clone 5.23 - JBC1931609 JBC1931609
      Anti-BRCA2, clone 5.23 -2744790 2744790


      Reference overviewApplicationPub Med ID
      BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.
      Ouyang, KJ; Yagle, MK; Matunis, MJ; Ellis, NA
      Frontiers in genetics  4  167  2013

      Show Abstract
      Immunofluorescence24027577 24027577
      A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
      Marmorstein, L Y, et al.
      Cell, 104: 247-57 (2001)  2001

      Show Abstract
      11207365 11207365
      Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
      Dignam, J D, et al.
      Nucleic Acids Res., 11: 1475-89 (1983)  1983

      Show Abstract
      6828386 6828386

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      Life Science Research > Antibodies and Assays > Primary Antibodies