CBL162 | Anti-CD9 Antibody, clone MM2/57

CBL162
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RbFC, IP, WB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL162
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD9 Antibody, clone MM2/57
      Alternate Names
      • MRP-1
      • DRAP-27
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-CD9 Antibody, clone MM2/57 detects level of CD9 & has been published & validated for use in FC, IP, WB, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry: Frozen sections of platelets, monocytes and pre-B cells with differential staining on lymphoid and epithelial tissues
      Platelet inhibition and aggregation studies
      Optimal working dilutions must be determined by the end user. the end user.
      Biological Information
      ImmunogenHuman platelet glycoprotein
      CloneMM2/57
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody reacts with a 25 kDa molecular weight band on gels of non-reduced platelet membranes and immunoprecipitates a similar band from Iodine125-labeled platelets. The antigen is expressed on eosinophils, granulocytes, monocytes and numerous stromal cells. This CD9 antigen belongs to the TM4 superfamily of cell surface proteins with the N- and C-terminals localized in the cytoplasm.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Mouse
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.
      Gene Symbol
      • CD9
      • Tspan-29
      • MRP-1
      • MIC3
      • p24
      • Tetraspanin-29
      • BA2
      • BTCC-1
      • 5H9
      • TSPAN29
      • GIG2
      • DRAP-27
      • P24
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21926 # Involved in platelet activation and aggregation. Regulates paranodal junction formation. Required for gamete fusion. Involved in cell adhesion, cell motility and tumor metastasis.
      SIZE: 228 amino acids; 25416 Da
      SUBUNIT: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed by a variety of hematopoietic and epithelial cells.
      PTM: Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. & Phosphorylated on tyrosine following B-cell activation.
      SIMILARITY: SwissProt: P21926 ## Belongs to the tetraspanin (TM4SF) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN CD9 MONOCLONAL ANTIBODY - 2135113 2135113
      MOUSE ANTI-HUMAN CD9 MONOCLONAL ANTIBODY - 2387529 2387529
      MOUSE ANTI-HUMAN CD9 - 2489019 2489019
      MOUSE ANTI-HUMAN CD9 -2514029 2514029
      MOUSE ANTI-HUMAN CD9 -2613109 2613109
      MOUSE ANTI-HUMAN CD9 -2673091 2673091
      MOUSE ANTI-HUMAN CD9 -2691299 2691299
      MOUSE ANTI-HUMAN CD9 -2726796 2726796
      MOUSE ANTI-HUMAN CD9 -2739151 2739151
      MOUSE ANTI-HUMAN CD9 -2810698 2810698

      References

      Reference overviewPub Med ID
      cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.
      Lanza, F, et al.
      J. Biol. Chem., 266: 10638-45 (1991)  1991

      Show Abstract
      2037603 2037603
      Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein.
      Carroll, R C, et al.
      Biochem. J., 266: 527-35 (1990)  1990

      2317202 2317202

      Brochure

      Title
      Human Stem Cell Systems

      Data Sheet

      Title
      Anti-CD9, clone MM2/57 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies