07-1491 | Anti-Calcineurin pan A Antibody

07-1491
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MaWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1491
      ReplacesAB1695
      DescriptionAnti-Calcineurin pan A Antibody
      Alternate Names
      • CAM-PRP catalytic subunit
      • Calmodulin-dependent calcineurin A subunit alpha isoform
      • calcineurin A alpha
      • protein phosphatase 3 (formerly 2B), catalytic subunit,
        alpha isoform
      • protein phosphatase 3 (formerly 2B), catalytic subunit,
        alpha isoform (calcineurin A alpha)
      • protein phosphatase 3, catalytic subunit, alpha isoform
      • serine/threonine-protein phosphatase 2B catalytic subunit
        alpha isoform
      Background InformationCalcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin's multifunctional capabilities in the regulation of calcium signaling.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse brain lysate
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.
      Applications
      ApplicationDetect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to Calcineurin.
      HostRabbit
      SpecificityThis antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.
      Species Reactivity
      • Mammals
      Species Reactivity NoteReacts with human, mouse, and rat. Predicted to react with all mammals based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CALN
      • CALNA
      • CALNA1
      • CCN1
      • CNA
      • CNA1
      • EC 3.1.3.16
      • PPP2B
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.
      CATALYTIC ACTIVITY: A phosphoprotein + H2O = a protein + phosphate.
      COFACTOR:Binds 1 Fe3+ ion per subunit.
      Binds 1 zinc ion per subunit.
      SUBUNIT STRUCTURE: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.
      SUBCELLULAR LOCATION: Nucleus By similarity. Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle By similarity.
      SEQUENCE SIMILARITIES: Belongs to the PPP phosphatase family. PP-2B subfamily.
      Molecular Weight~58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Mouse brain lysate.
      Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
      remain unfrozen.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Calcineurin pan A - 2390887 2390887
      Anti-Calcineurin pan A - 2450174 2450174
      Anti-Calcineurin pan A - 1987081 1987081
      Anti-Calcineurin pan A - 2038284 2038284
      Anti-Calcineurin pan A - 2074068 2074068
      Anti-Calcineurin pan A - 2228132 2228132
      Anti-Calcineurin pan A - JBC1771291 JBC1771291
      Anti-Calcineurin pan A - NG1894433 NG1894433
      Anti-Calcineurin pan A - NG1931394 NG1931394
      Anti-Calcineurin pan A - NRG1688797 NRG1688797

      References

      Reference overviewPub Med ID
      Atypical behavior of NFATc1 in cultured intercostal myofibers.
      Robison, P; Hernández-Ochoa, EO; Schneider, MF
      Skeletal muscle  4  1  2014

      Show Abstract
      24383888 24383888
      Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression.
      Bala, K; Bosco, R; Gramolelli, S; Haas, DA; Kati, S; Pietrek, M; Hävemeier, A; Yakushko, Y; Singh, VV; Dittrich-Breiholz, O; Kracht, M; Schulz, TF
      PLoS pathogens  8  e1002927  2012

      Show Abstract
      23028325 23028325
      Sustained postexercise increases in AS160 Thr642 and Ser588 phosphorylation in skeletal muscle without sustained increases in kinase phosphorylation.
      Schweitzer, GG; Arias, EB; Cartee, GD
      Journal of applied physiology (Bethesda, Md. : 1985)  113  1852-61  2012

      Show Abstract
      22936728 22936728
      Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes.
      Lina Wang,Feng Guo,Shi Wei,Ruqian Zhao
      Peptides  32  2011

      Show Abstract
      21453734 21453734

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies