07-259 | Anti-δ-Catenin Antibody

07-259
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-259
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-δ-Catenin Antibody
      Alternate Names
      • Catenin delta-2
      • Delta-catenin
      • Neural plakophilin-related ARM-repeat protein
      • Neurojungin
      • NPRAP
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-δ-Catenin Antibody detects level of δ-Catenin & has been published & validated for use in WB. This Catenin delta-2 antibody has been validated for use in Mouse and Rat.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 1-461 of mouse delta Catenin
      EpitopeA.a. 1-461
      HostRabbit
      Specificitydelta Catenin
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Ctnnd2
      • Catnd2
      • Nprap
      Purification MethodProtein A purified.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O35927 # Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:17993462) (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (PubMed:15282317).
      SIZE: 1247 amino acids; 135000 Da
      SUBUNIT: Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1. Interacts with PDZD2 (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (By similarity). Interacts with ZBTB33. Interacts with ARHGEF28 (PubMed:17993462). Interacts with CDK5 (By similarity). Interacts with CTNNB1 (By similarity). Interacts with GSK3A and GSK3B (PubMed:20623542) (PubMed:19706605). Interacts with DNM2 (By similarity).
      SUBCELLULAR LOCATION: Nucleus. Cell junction, adherens junction. Cell projection, dendrite. Perikaryon (By similarity).
      TISSUE SPECIFICITY: Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions.
      PTM: O-glycosylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: O35927 ## Belongs to the beta-catenin family. & Contains 9 ARM repeats.
      Molecular Weight133kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on rat brain microsomes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-delta;-Catenin - 22056 22056

      References

      Reference overviewPub Med ID
      Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.
      Gu, D; Tonthat, NK; Lee, M; Ji, H; Bhat, KP; Hollingsworth, F; Aldape, KD; Schumacher, MA; Zwaka, TP; McCrea, PD
      The Journal of biological chemistry  286  23178-88  2011

      Show Abstract
      21561870 21561870
      Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation.
      Kim, H; Han, JR; Park, J; Oh, M; James, SE; Chang, S; Lu, Q; Lee, KY; Ki, H; Song, WJ; Kim, K
      The Journal of biological chemistry  283  977-87  2008

      Show Abstract
      17993462 17993462
      Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
      Thelemann, A; Petti, F; Griffin, G; Iwata, K; Hunt, T; Settinari, T; Fenyo, D; Gibson, N; Haley, JD
      Molecular & cellular proteomics : MCP  4  356-76  2005

      Show Abstract
      15657067 15657067