05-579 Anti-Endostatin Antibody, clone 1837.46

200 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCMPurifiedMonoclonal Antibody
      Catalogue Number05-579
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Endostatin Antibody, clone 1837.46
      Product Information
      Presentation50mM sodium phosphate, pH 8.0, 0.05% sodium azide, before the addition of glycerol to 30%
      ApplicationAnti-Endostatin Antibody, clone 1837.46 is an antibody against Endostatin for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenFull-length recombinant murine endostatin
      Cloneclone 1837.46
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • COL18A1
      • MGC74745
      • endostatin
      • KNO
      • FLJ27325
      Purification MethodThiophilic chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P39060 # Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
      SIZE: 1754 amino acids; 178160 Da
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
      TISSUE SPECIFICITY: Present in multiple organs with highest levels in liver, lung and kidney.
      PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
      DISEASE: SwissProt: P39060 # Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
      SIMILARITY: SwissProt: P39060 ## Belongs to the multiplexin collagen family. & Contains 1 FZ (frizzled) domain. & Contains 1 TSP N-terminal (TSPN) domain.
      Molecular WeightRecognizes endostatin, Mr 22kDa. An unidentified protein is also weakly detected at Mr 54kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on 3T3 cell lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Endostatin (mouse monoclonal IgG)2890794
      Anti-Endostatin (mouse monoclonal IgG) - 13502841350284
      Anti-Endostatin (mouse monoclonal IgG) - 19464041946404
      Anti-Endostatin (mouse monoclonal IgG) -24945302494530
      Anti-Endostatin - DAM1523927DAM1523927
      Anti-Endostatin - DAM1614909DAM1614909
      Anti-Endostatin - DAM1718043DAM1718043
      Anti-Endostatin - DAM1813168DAM1813168
      Anti-Endostatin -25178732517873
      Anti-Endostatin -28511452851145


      Reference overviewApplicationPub Med ID
      Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.
      Gunsalus, KT; Wagoner, MP; Meyer, K; Potter, WB; Schoenike, B; Kim, S; Alexander, CM; Friedl, A; Roopra, A
      Cancer research  72  3207-16  2012

      Show Abstract
      Western Blotting22532168 22532168
      Localization of endostatin in rat and human gliomas
      Strik, H. M., et al
      Cancer, 91:1013-9 (2001)  2001

      Immunohistochemistry (Tissue)11251954 11251954
      Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases.
      Sauter, B V, et al.
      Proc. Natl. Acad. Sci. U.S.A., 97: 4802-7 (2000)  2000

      Show Abstract
      10758166 10758166
      Endostatin induces endothelial cell apoptosis.
      Dhanabal, M, et al.
      J. Biol. Chem., 274: 11721-6 (1999)  1999

      Show Abstract
      10206987 10206987