05-502 | Anti-FRS2/SNT-1 Antibody

05-502
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-502
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-FRS2/SNT-1 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
      Applications
      ApplicationDetect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to residues 283-297 of human FRS2/SNT-1
      HostMouse
      SpecificityFRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FRS2
      • SNT1
      • FRS2A
      • SNT-1
      • SNT
      • FRS2alpha
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8WU20 # Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
      SIZE: 512 amino acids; 57528 Da
      SUBUNIT: Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine- phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.
      SUBCELLULAR LOCATION: Intracytoplasmic membrane. Note=Cytoplasmic, membrane-bound.
      TISSUE SPECIFICITY: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
      PTM: Phosphorylated on tyrosine residues upon stimulation by NGF. & Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
      SIMILARITY: SwissProt: Q8WU20 ## Contains 1 IRS-type PTB domain.
      Molecular Weightnon-phosphorylated (68kDa) and phosphorylated (83kDa)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-FRS2/SNT-1 2470903
      Anti-FRS2/SNT-1 (mouse monoclonal IgG) 2944489
      Anti-FRS2/SNT-1 (mouse monoclonal IgG) - DAM1486575 DAM1486575
      Anti-FRS2/SNT-1 - 19147 19147
      Anti-FRS2/SNT-1 - JBC1381946 JBC1381946
      Anti-FRS2/SNT-1 - JBC1381946 JBC1381946

      References

      Reference overviewPub Med ID
      Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells.
      Zhanbing Liu, Toshiyuki Ishiwata, Shaxia Zhou, Susanne Maier, Doris Henne-Bruns, Murray Korc, Max Bachem, Marko Kornmann
      Pancreas  35  147-57  2007

      Show Abstract
      17632321 17632321
      The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.
      Meakin, S O, et al.
      J. Biol. Chem., 274: 9861-70 (1999)  1999

      Show Abstract
      10092678 10092678
      Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
      Hadari, Y R, et al.
      Mol. Cell. Biol., 18: 3966-73 (1998)  1998

      Show Abstract
      9632781 9632781
      Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
      Xu, H, et al.
      J. Biol. Chem., 273: 17987-90 (1998)  1998

      Show Abstract
      9660748 9660748