05-468 | Anti-FcεRI α subunit Antibody

05-468
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RFC, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-468
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-FcεRI α subunit Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, 0.15M NaCl, 0.05% sodium azide prior to the addition of glycerol to 30%
      Applications
      ApplicationAnti-FcεRI α subunit Antibody is an antibody against FcεRI α subunit for use in FC & IP.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      Application NotesWestern blot is not recommended
      Biological Information
      ImmunogenWhole rat basophilic leukemia cells, positive for the rat high-affinity receptor recognizing immunoglobulin E (FcεRI).
      HostMouse
      SpecificityFcεRIα
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM]
      Gene Symbol
      • FCER1A
      • FcERI
      • FCE1A
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P12319 # Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
      SIZE: 257 amino acids; 29596 Da
      SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P12319 ## Contains 2 Ig-like (immunoglobulin-like) domains.
      Molecular Weight45-55kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitation of rat FcεRIα from biotinylated rat basophilic leukemia cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fcepsilon;RI alpha; subunit - 16407 16407
      Anti-Fcepsilon;RI alpha; subunit - 20959 20959
      Anti-Fcepsilon;RI alpha; subunit - 23853 23853
      Anti-FcεRI α -2887232 2887232
      Anti-FcRI (mouse monoclonal IgG1) 2896053

      References

      Reference overviewPub Med ID
      Glycosylation of human truncated Fc epsilon RI alpha chain is necessary for efficient folding in the endoplasmic reticulum.
      Letourneur, O, et al.
      J. Biol. Chem., 270: 8249-56 (1995)  1995

      Show Abstract
      7713932 7713932

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies