06-174 | Anti-Fms/CSF-1 Receptor Antibody, extracellular domain

06-174
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, ICC, IP, WBRbSerumPolyclonal Antibody
      Description
      Catalogue Number06-174
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Fms/CSF-1 Receptor Antibody, extracellular domain
      Alternate Names
      • CSF-1R
      References
      Product Information
      FormatSerum
      Presentationwhole rabbit antiserum
      Applications
      ApplicationThis Anti-Fms/CSF-1 Receptor Antibody, extracellular domain is validated for use in FC, IC, IP, WB for the detection of Fms/CSF-1 Receptor.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenRab9 rabbit skin fibroblast cells transfected with a fully activated (transforming) murine Fms gene
      HostRabbit
      Specificityextracellular domain of mouse Fms encoded protein
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
      Gene Symbol
      • CSF1R
      • C-FMS
      • FMS
      • FIM2
      • c-fms
      • CSF-1-R
      • CSFR
      • CD115
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.
      SIZE: 972 amino acids; 107984 Da
      SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.
      SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular WeightObserved molecular weight at ~220 kDa, theoretical molecular weight at 150-165 kDa. Lower molecular weight degradation products may also be detected.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on FDC-P1/MAC11 cell lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fms/CSF-1 R extracellular domain - 16212 16212
      Anti-Fms/CSF-1 R extracellular domain - 17406 17406
      Anti-Fms/CSF-1 R extracellular domain - 21328 21328
      Anti-Fms/CSF-1 R extracellular domain - 26040 26040
      Anti-Fms/CSF-1 R extracellular domain - 33538 33538
      Anti-Fms/CSF-1 R, extracellular domain 2470916
      Anti-Fms/CSF-1 R, extracellular domain (rabbit antiserum) - 2450171 2450171
      Anti-Fms/CSF-1 R, extracellular domain (rabbit antiserum) - 1957276 1957276
      Anti-Fms/CSF-1 R, extracellular domain (rabbit antiserum) - 2038658 2038658
      Anti-Fms/CSF-1 R, extracellular domain (rabbit antiserum) - 2203118 2203118

      References

      Reference overviewApplicationPub Med ID
      The CSF-1 receptor fashions the intestinal stem cell niche.
      Akcora, D; Huynh, D; Lightowler, S; Germann, M; Robine, S; de May, JR; Pollard, JW; Stanley, ER; Malaterre, J; Ramsay, RG
      Stem cell research  10  203-12  2013

      Show Abstract
      23314290 23314290
      Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase.
      Zwaenepoel, O; Tzenaki, N; Vergetaki, A; Makrigiannakis, A; Vanhaesebroeck, B; Papakonstanti, EA
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  26  691-706  2012

      Show Abstract
      22084313 22084313
      Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts.
      Wittrant, Y; Gorin, Y; Mohan, S; Wagner, B; Abboud-Werner, SL
      Endocrinology  150  4977-88  2009

      Show Abstract
      Western Blotting19819976 19819976
      Analysis of immune cell infiltrates during squamous carcinoma development.
      Simon R Junankar, Alexandra Eichten, Annegret Kramer, Karin E de Visser, Lisa M Coussens
      The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research  11  36-43  2006

      Show Abstract
      17069009 17069009
      Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation.
      Kirma, N; Luthra, R; Jones, J; Liu, YG; Nair, HB; Mandava, U; Tekmal, RR
      Cancer research  64  4162-70  2004

      Show Abstract
      15205327 15205327
      Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells.
      S Murase, Y Hayashi, S Murase, Y Hayashi
      The Journal of neuroscience : the official journal of the Society for Neuroscience  18  10481-92  1998

      Show Abstract
      9852586 9852586
      The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.
      Carlberg, K and Rohrschneider, L
      Mol. Biol. Cell, 5: 81-95 (1994)  1994

      Show Abstract
      7514458 7514458

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies