05-903 | Anti-GSK3α/β Antibody, rabbit monoclonal

05-903
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-903
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-GSK3α/β Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Applications
      ApplicationAnti-GSK3α/β Antibody is an antibody against GSK3α/β for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenN-terminal 6His-tagged recombinant full length human GSK3β
      HostRabbit
      SpecificityGSK3 alpha and beta
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NotePredicted to cross-react with rat based on sequence homology
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
      Gene Symbol
      • GSK3A
      • DKFZp686D0638
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).
      SIZE: 483 amino acids; 50981 Da
      SUBUNIT: Monomer (By similarity).
      SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
      Molecular WeightMr 46kDa (beta) and 51kDa (alpha)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on lysates from HEK293 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-GSK3#945;/#946; - DAM1805240 DAM1805240
      Anti-GSK3/ (rabbit monoclonal IgG) - 2332510 2332510
      Anti-GSK3/ - DAM1776427 DAM1776427
      Anti-GSK3alpha;/beta; - 30381 30381
      Anti-GSK3α/β (rabbit monoclonal IgG) - 2429682 2429682
      Anti-GSK3α/β -2582852 2582852
      Anti-GSK3α/β -2613732 2613732
      Anti-GSK3α/β -2686901 2686901

      References

      Reference overviewApplicationPub Med ID
      AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
      Pan, JQ; Lewis, MC; Ketterman, JK; Clore, EL; Riley, M; Richards, KR; Berry-Scott, E; Liu, X; Wagner, FF; Holson, EB; Neve, RL; Biechele, TL; Moon, RT; Scolnick, EM; Petryshen, TL; Haggarty, SJ
      Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  36  1397-411  2011

      Show Abstract
      21389981 21389981
      Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.
      Chuluunbaatar, U; Roller, R; Feldman, ME; Brown, S; Shokat, KM; Mohr, I
      Genes & development  24  2627-39  2010

      Show Abstract
      21123650 21123650
      The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.
      Castaño, Zafira, et al.
      J. Neurochem., 113: 117-30 (2010)  2010

      Show Abstract
      20067585 20067585
      The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.
      Dormoy, V; Danilin, S; Lindner, V; Thomas, L; Rothhut, S; Coquard, C; Helwig, JJ; Jacqmin, D; Lang, H; Massfelder, T
      Molecular cancer  8  123  2009

      Show Abstract
      Western Blotting20015350 20015350
      GSK-3 inhibitors: discoveries and developments.
      Alonso, M and Martinez, A
      Curr. Med. Chem., 11: 755-63 (2004)  2004

      Show Abstract
      15032729 15032729
      Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes.
      Jope, Richard S
      Trends Pharmacol. Sci., 24: 441-3 (2003)  2003

      Show Abstract
      12967765 12967765
      GSK-3: tricks of the trade for a multi-tasking kinase.
      Doble, Bradley W and Woodgett, James R
      J. Cell. Sci., 116: 1175-86 (2003)  2003

      Show Abstract
      12615961 12615961

      Newsletters / Publications

      Title
      Research Focus - Volume 2, 2013

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies