04-921 | Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

04-921
100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number04-921
      Replaces05-921
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-GluR6/7 Antibody, clone NL9, rabbit monoclonal
      References
      Product Information
      FormatCulture Supernatant
      Control
      • Mouse brain tissue, rat brain microsomal preparation, human brain lysates
      Applications
      ApplicationAnti-GluR6/7 Antibody, clone NL9 is an antibody against GluR6/7 for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 894-908 (C-terminus) of rat GluR6. The immunizing sequence is identical in human.
      CloneNL904
      HostRabbit
      SpecificityRecognizes GluR6/7.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
      Gene Symbol
      • GRIK2
      • GLR6
      • EAA4
      • GluR-6
      • GLUR6
      • MGC74427
      • GluR6
      Purification MethodNone
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13002 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
      SIZE: 908 amino acids; 102583 Da
      SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expression is higher in cerebellum than in cerebral cortex.
      SIMILARITY: SwissProt: Q13002 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > quisqualate > 6- cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.
      Molecular Weight115 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-GluR6/7, clone NL9 2470962
      Anti-GluR6/7, clone NL9 - 2128267 2128267
      Anti-GluR6/7, clone NL9 - 2006966 2006966
      Anti-GluR6/7, clone NL9 - 2201489 2201489
      Anti-GluR6/7, clone NL9 - 2360565 2360565
      Anti-GluR6/7, clone NL9 - DAM1497226 DAM1497226
      Anti-GluR6/7, clone NL9 - NG1740966 NG1740966
      Anti-GluR6/7, clone NL9 - NG1800783 NG1800783
      Anti-GluR6/7, clone NL9 - NG1867616 NG1867616
      Anti-GluR6/7, clone NL9 -2585816 2585816

      References

      Reference overviewPub Med ID
      Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses.
      Wyeth, MS; Pelkey, KA; Petralia, RS; Salter, MW; McInnes, RR; McBain, CJ
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  622-8  2014

      Show Abstract
      24403160 24403160
      Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis.
      Copits, BA; Swanson, GT
      The Journal of biological chemistry  288  8952-65  2013

      Show Abstract
      23400781 23400781
      Mapping the Ligand Binding Sites of Kainate Receptors: Molecular Determinants of Subunit-Selective Binding of the Antagonist [3H]UBP310.
      Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnár E
      Mol Pharmacol  78  1036-45. Epub 2010 Sep 13.  2010

      Show Abstract
      20837679 20837679
      Evidence for a role of glutamate as an efferent transmitter in taste buds.
      Vandenbeuch A, Tizzano M, Anderson CB, Stone LM, Goldberg D, Kinnamon SC
      BMC Neurosci  11  77.  2010

      Show Abstract Full Text Article
      20565975 20565975

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer