05-1571 | Anti-IGF-1R Antibody, clone 24-57

05-1571
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1571
      DescriptionAnti-IGF-1R Antibody, clone 24-57
      Alternate Names
      • CD221 antigen
      • IGF-I receptor
      • Insulin-like growth factor I receptor
      • insulin-like growth factor 1 receptor
      • soluble IGF1R variant 1
      • soluble IGF1R variant 2
      Background InformationThere are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kDa) and two beta (95 kDa) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
      References
      Product Information
      FormatPurified
      Control
      • Human placental villi and tonsil tissue
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-IGF-1R Antibody, clone 24-57 is validated for use in IH, IP for the detection of IGF-1R.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Soos, M., et al. (1992). Journal of Biological Chemistry. 267(18):12955-12963.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IGF-IR.
      EpitopeUnknown
      Clone24-57
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes IGF-IR.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq].
      Gene Symbol
      • IGF1R
      • CD221
      • IGFIR
      • IGFR
      • JTK13
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.

      SIZE: 1367 amino acids; 154793 Da

      SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Expressed in a variety of tissues.

      PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin- like growth factor I (IGF I). & Phosphorylation of Tyr-980 is required for IRS1- and SHC1- binding.

      DISEASE: Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a growth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.

      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 3 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight155 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human placental villi and tonsil tissue.

      Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected IGF-1R in human placental villi and tonsil tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IGF-1R, clone 24-57 2485684
      Anti-IGF-1R, clone 24-57 - 2410231 2410231
      Anti-IGF-1R, clone 24-57 - 2066717 2066717
      Anti-IGF-1R, clone 24-57 - 2205005 2205005
      Anti-IGF-1R, clone 24-57 - NG1838620 NG1838620
      Anti-IGF-1R, clone 24-57 - NRG1697045 NRG1697045
      Anti-IGF-1R, clone 24-57 -2547204 2547204
      Anti-IGF-1R, clone 24-57 -2562453 2562453
      Anti-IGF-1R, clone 24-57 -2588512 2588512
      Anti-IGF-1R, clone 24-57 -2636705 2636705

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies