05-656 | Anti-IGF-IR Antibody, clone JBW902

05-656
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIHC, IP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-656
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IGF-IR Antibody, clone JBW902
      Background InformationThere are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kDa) and two beta (95 kDa) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
      References
      Product Information
      FormatPurified
      Control
      • C4 cell lysate, HepG2 cells
      PresentationProtein A Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide and 30% glycerol.
      Applications
      ApplicationAnti-IGF-IR Antibody, clone JBW902 detects level of IGF-IR & has been published & validated for use in IH, IP & WB.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 1264-1367 of human IGF-1 Receptor
      CloneJBW902
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes IGF-1 receptor b chain; does not cross react with insulin receptor.
      IsotypeIgG2a
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
      Gene Symbol
      • IGF1R
      • IGFIR
      • MGC18216
      • MGC142170
      • JTK13
      • MGC142172
      • CD221
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08069 # This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.
      SIZE: 1367 amino acids; 154793 Da
      SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in a variety of tissues.
      PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin- like growth factor I (IGF I). & Phosphorylation of Tyr-980 is required for IRS1- and SHC1- binding.
      DISEASE: SwissProt: P08069 # Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.
      SIMILARITY: SwissProt: P08069 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 3 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight95 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from C4 cells (mouse 3T3 cells that have been transfected with the human IGF-1 Receptor)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IGF-1 R, clone JBW902 (mouse monoclonal IgG2a) - 2441915 2441915
      Anti-IGF-1 R, clone JBW902 (mouse monoclonal IgG2a) 2908594
      Anti-IGF-1 R, clone JBW902 - 22215 22215
      Anti-IGF-1 R, clone JBW902 - 2517875 2517875
      Anti-IGF-1 R, clone JBW902 - DAM1564511 DAM1564511
      Anti-IGF-1 R, clone JBW902 -2583377 2583377
      Anti-IGF-1 R, clone JBW902 -2686894 2686894
      AntiAnti -IGFIGF -1 R, clone JBW902 -2794804 2794804

      References

      Reference overviewApplicationPub Med ID
      Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
      Mroue, R; Huang, B; Braunstein, S; Firestone, AJ; Nakamura, JL
      PLoS genetics  11  e1005235  2015

      Show Abstract
      26000738 26000738
      MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells.
      Choo, KB; Soon, YL; Nguyen, PN; Hiew, MS; Huang, CJ
      Journal of biomedical science  21  95  2014

      Show Abstract
      Western Blotting25287248 25287248
      Regulation of insulin-like growth factor I receptors in diabetic mesangial cells.
      Oemar, B S, et al.
      J. Biol. Chem., 266: 2369-73 (1991)  1991

      Show Abstract
      1846626 1846626
      Identification of retinal insulin receptors using site-specific antibodies to a carboxyl-terminal peptide of the human insulin receptor alpha-subunit. Up-regulation of neuronal insulin receptors in diabetes.
      Rosenzweig, S A, et al.
      J. Biol. Chem., 265: 18030-4 (1990)  1990

      Show Abstract
      2211678 2211678

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      Alternative Packsize

      Catalogue Number Description  
      05-656-KC Anti-IGF-IR, clone JBW902 (1mg) KC Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies