06-429 Anti-IGF-IRα subunit Antibody

250 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, IP, WBChPurifiedPolyclonal Antibody
      Catalogue Number06-429
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IGF-IRα subunit Antibody
      Product Information
      • C4 cell lysate, HepG2 cells
      PresentationProtein A Purified immunoglobulin in 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
      ApplicationAnti-IGF-IRα subunit Antibody detects level of IGF-IRα subunit & has been published & validated for use in IC, IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogen19 residue synthetic peptide [C-KYADGTIDIEEVTENPKT] corresponding to amino acid residues (642-659) of human IGF-I receptor alpha-subunit
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes IGF-I receptor alpha-subunit.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
      Gene Symbol
      • IGF1R
      • MGC142170
      • IGFIR
      • MGC18216
      • JTK13
      • MGC142172
      • CD221
      Purification MethodAmmonium Sulfate Precipitation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08069 # This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.
      SIZE: 1367 amino acids; 154793 Da
      SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in a variety of tissues.
      PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin- like growth factor I (IGF I). & Phosphorylation of Tyr-980 is required for IRS1- and SHC1- binding.
      DISEASE: SwissProt: P08069 # Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.
      SIMILARITY: SwissProt: P08069 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 3 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight130 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on membranes prepared from 3T3 cells expressing the human IGF-I receptor
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IGF-I Receptor #945; subunit - DAM1724033DAM1724033
      Anti-IGF-I Receptor a subunit (chicken polyclonal IgY) - 19464461946446
      Anti-IGF-I Receptor a subunit (chicken polyclonal IgY) - 21872202187220
      Anti-IGF-I Receptor a subunit (chicken polyclonal IgY) - DAM1411334DAM1411334
      Anti-IGF-I Receptor a subunit - DAM1513994DAM1513994
      Anti-IGF-I Receptor a subunit - JBC1885058JBC1885058
      Anti-IGF-IRalpha; subunit - 1449314493
      Anti-IGF-IRalpha; subunit - 1591415914
      Anti-IGF-IRalpha; subunit - 2149421494
      Anti-IGF-IRalpha; subunit - 2334923349


      Reference overviewApplicationPub Med ID
      Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation.
      Beauvais, DM; Rapraeger, AC
      Journal of cell science  123  3796-807  2010

      Show Abstract
      20971705 20971705
      Immunogold labeling of insulin growth factor-I receptors in elderly human skeletal muscle.
      Maria Urso, Arthur Cosmas, Maria Fiatarone Singh, Thomas Manfredi
      Scanning  27  208-12  2005

      Show Abstract
      16089305 16089305
      The matrix metalloproteinase-9 regulates the insulin-like growth factor-triggered autocrine response in DU-145 carcinoma cells
      Manes, S., et al
      J Biol Chem, 274:6935-45 (1999)  1999

      Immunoprecipitation10066747 10066747
      Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance.
      Leventhal, P S, et al.
      J. Biol. Chem., 272: 5214-8 (1997)  1997

      Show Abstract
      Immunocytochemistry9030591 9030591
      Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit
      Mynarcik, D. C., et al
      J Biol Chem, 271:2439-42 (1996)  1996

      Immunoblotting (Western)8576204 8576204
      Cryogenic spinal cord injury induces astrocytic gene expression of insulin-like growth factor I and insulin-like growth factor binding protein 2 during myelin regeneration
      Yao, D. L., et al
      J Neurosci Res, 40:647-59 (1995)  1995

      Immunohistochemistry (Tissue)7541476 7541476
      Regulation of insulin-like growth factor I receptors in diabetic mesangial cells.
      Oemar, B S, et al.
      J. Biol. Chem., 266: 2369-73 (1991)  1991

      Show Abstract
      1846626 1846626
      Identification of retinal insulin receptors using site-specific antibodies to a carboxyl-terminal peptide of the human insulin receptor alpha-subunit. Up-regulation of neuronal insulin receptors in diabetes.
      Rosenzweig, S A, et al.
      J. Biol. Chem., 265: 18030-4 (1990)  1990

      Show Abstract
      2211678 2211678

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      Life Science Research > Antibodies and Assays > Primary Antibodies