05-170 | Anti-IL-2 Rα Antibody, clone 7G7/B6

200 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HDB, ICCMPurifiedMonoclonal Antibody
      Catalogue Number05-170
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IL-2 Rα Antibody, clone 7G7/B6
      Product Information
      • Lung tissue
      PresentationProtein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
      ApplicationThis Anti-IL-2 Rα Antibody, clone 7G7/B6 is validated for use in DB, IC for the detection of IL-2 Rα.
      Key Applications
      • Dot Blot
      • Immunocytochemistry
      Biological Information
      ImmunogenWhole cells expressing human IL-2 Receptor α
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes interleukin-2 receptor.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.
      Gene Symbol
      • IL2RA
      • CD25
      • IL2-RA
      • IL-2-RA
      • OTTHUMP00000044870
      • TCGFR
      • IL2R
      • IDDM10
      • p55
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01589 # Receptor for interleukin-2.
      SIZE: 272 amino acids; 30819 Da
      SUBUNIT: Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE:SwissProt: P01589 # Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].
      SIMILARITY: SwissProt: P01589 ## Contains 2 Sushi (CCP/SCR) domains.
      Molecular Weight55 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated on ice cold ethanol/acetic acid [95:5] fixed phytohemagglutinin (PHA)-treated Jurkat T lymphocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-2 Ralpha;, clone 7G7/B6 - 15849 15849
      Anti-IL-2 Ralpha;, clone 7G7/B6 - 19237 19237
      Anti-IL-2 Ralpha;, clone 7G7/B6 - 23187 23187
      Anti-IL-2 Ralpha;, clone 7G7/B6 - 30215 30215
      Anti-IL-2 Receptor #945;, clone 7G7/B6 (mouse monoclonal IgG2a) - DAM1778022 DAM1778022
      Anti-IL-2 Receptor a, clone 7G7/B6 (mouse monoclonal IgG2a) 2884132
      Anti-IL-2 Receptor a, clone 7G7/B6 (mouse monoclonal IgG2a) - 2023278 2023278
      Anti-IL-2 Receptor a, clone 7G7/B6 (mouse monoclonal IgG2a) - 2155403 2155403
      Anti-IL-2 Receptor a, clone 7G7/B6 - 2047781 2047781
      Anti-IL-2 Receptor a, clone 7G7/B6 - DAM1718030 DAM1718030


      Reference overviewApplicationPub Med ID
      A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.
      Tomida, J; Itaya, A; Shigechi, T; Unno, J; Uchida, E; Ikura, M; Masuda, Y; Matsuda, S; Adachi, J; Kobayashi, M; Meetei, AR; Maehara, Y; Yamamoto, K; Kamiya, K; Matsuura, A; Matsuda, T; Ikura, T; Ishiai, M; Takata, M
      Nucleic acids research  41  6930-41  2013

      Show Abstract
      23723247 23723247
      Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development.
      Chen, L; Segal, D; Hukriede, NA; Podtelejnikov, AV; Bayarsaihan, D; Kennison, JA; Ogryzko, VV; Dawid, IB; Westphal, H
      Proceedings of the National Academy of Sciences of the United States of America  99  14320-5  2002

      Show Abstract
      Flow Cytometry12381786 12381786
      The role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase phosphorylation
      Tahiliani, P. D., et al
      J Biol Chem, 272:7892-8 (1997)  1997

      Immunoblotting (Western)9065456 9065456
      A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells
      Lai, K. S., et al
      J Biol Chem, 270:25028-36 (1995)  1995

      Immunoprecipitation7559633 7559633
      A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac.
      Rubin, L A, et al.
      Hybridoma, 4: 91-102 (1985)  1985

      Show Abstract
      2408992 2408992

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      Life Science Research > Antibodies and Assays > Primary Antibodies