06-1331 | Anti-IL-23R Antibody, cytoplasmic

06-1331
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHC, ELISA, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1331
      DescriptionAnti-IL-23R Antibody, cytoplasmic
      Alternate Names
      • interleukin 23 receptor
      Background InformationInterleukin 23 receptor (IL-23R) is a type I cytokine receptor that is a subunit of the receptor for IL23A/IL23. IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. IL-23R associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Jurkat cell lysate
      PresentationPurified rabbit polyclonal in PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-IL-23R Antibody, cytoplasmic detects level of IL-23R & has been published & validated for use in WB, IH, ELISA, FC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • ELISA
      • Flow Cytometry
      Application NotesImmunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-23R in mouse spleen tissue.

      Flow Cytometry Analysis: 2-10 µg from a previous lot detected IL-23R in human PBMCs. Does not work in mouse for flow cytometry.

      ELISA: A previous lot of this antibody was tested on ELISA by an independent laboratory.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IL-23R at and around the cytoplasmic domain.
      EpitopeCytoplasmic Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the cytoplasmic domain of IL-23R.
      May detect other isoforms of IL-23R (see molecular weight).
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteProven to react with human and mouse.
      Does not work for mouse in flow cytometry.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq]
      Gene Symbol
      • il23r
      • IBD17
      • IL-23R
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

      SUBUNIT STRUCTURE: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

      PTM: Phosphorylated in response to IL23.

      INVOLVEMENT IN DISEASE: Genetic variation in IL23R is associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. Inflammatory bowel disease (IBD) is a form of remitting Crohn disease (CD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. CD is commonly classified as an autoimmune disease.

      Genetic variation in IL23R is associated with susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease.

      Genetic variation in IL23R is associated with susceptibility to psoriasis [MIM:177900]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age.

      SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 2 subfamily.

      Contains 2 fibronectin type-III domains.
      Molecular Weight~42 kDa Observed.
      May detect other isoforms of IL-23R produced by alternative splicing: isoform 1 (~72 kDa), isoform 2 (~43 kDa), isoform 3 (~41 kDa), isoform 4 (~20 kDa), isoform 5 (~30 kDa), isoform 6 (~43 kDa) and isoform 7 (~26 kDa).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected IL-23R on 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-23R, cytoplasmic - 2119003 2119003
      Anti-IL-23R, cytoplasmic - 2145095 2145095
      Anti-IL-23R, cytoplasmic - 2387807 2387807
      Anti-IL-23R, cytoplasmic - 2179368 2179368
      Anti-IL-23R, cytoplasmic - 2279248 2279248
      Anti-IL-23R, cytoplasmic - 2328027 2328027
      Anti-IL-23R, cytoplasmic - NG1734254 NG1734254
      Anti-IL-23R, cytoplasmic - NG1809957 NG1809957
      Anti-IL-23R, cytoplasmic - NG1868831 NG1868831
      Anti-IL-23R, cytoplasmic - NG1916523 NG1916523

      References

      Reference overviewPub Med ID
      Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center.
      S Biggins,I Ivanovska,M D Rose
      The Journal of cell biology  133  1996

      Show Abstract Full Text Article
      8682868 8682868