05-246 | Anti-Integrin α1 Antibody, clone 5E8D9

200 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, NEUTMPurifiedMonoclonal Antibody
      Catalogue Number05-246
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Integrin α1 Antibody, clone 5E8D9
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl
      ApplicationAnti-Integrin α1 Antibody, clone 5E8D9 is an antibody against Integrin α1 for use in IC, NEUT.
      Key Applications
      • Immunocytochemistry
      • Neutralizing
      Biological Information
      ImmunogenPurified human integrinα1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
      Gene Symbol
      • ITGA1
      • CD49a
      • VLA1
      • VLA-1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P56199 # Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen.
      SIZE: 1179 amino acids; 130848 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P56199 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
      SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
      Molecular Weight150kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated on cold ethanol fixed cells in immunocytochemistry
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Integrin alpha;1, clone 5E8D9 - 13082 13082
      Anti-Integrin alpha;1, clone 5E8D9 - 19465 19465
      Anti-Integrin alpha;1, clone 5E8D9 - 24929 24929
      Anti-Integrin alpha;1, clone 5E8D9 - 29863 29863
      Anti-Integrin α1 (human), clone 5E8D9 (mouse monoclonal IgG2a) 3052943
      Anti-Integrin 1 (human), clone 5E8D9 -2775446 2775446


      Reference overviewApplicationPub Med ID
      Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1
      Makihira, S., et al
      J Biol Chem, 274:11417-23 (1999)  1999

      Inhibits Activity/Function10196235 10196235
      Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98.
      S Chandrasekaran, N H Guo, R G Rodrigues, J Kaiser, D D Roberts
      The Journal of biological chemistry  274  11408-16  1999

      Show Abstract
      Immunofluorescence, Flow Cytometry10196234 10196234
      The integrin alpha1 A-domain is a ligand binding site for collagens and laminin
      Calderwood, D. A., et al
      J Biol Chem, 272:12311-7 (1997)  1997

      9139675 9139675
      Regulation of polymorphonuclear leukocyte cytokine receptor expression: the role of altered oxygen tensions and matrix proteins
      Simms, H. and D'Amico, R.
      J Immunol, 157:3605-16 (1996)  1996

      Cell Culture8871661 8871661
      Functional regulation of the human integrin VLA-1 (CD49a/CD29) by divalent cations and stimulatory beta 1 antibodies.
      Luque, A, et al.
      FEBS Lett., 346: 278-84 (1994)  1994

      Show Abstract
      7516898 7516898
      Regulation of the VLA integrin-ligand interactions through the beta 1 subunit.
      Arroyo, A G, et al.
      J. Cell Biol., 117: 659-70 (1992)  1992

      1374069 1374069

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      Life Science Research > Antibodies and Assays > Primary Antibodies