05-769 | Anti-Integrin β3 (CD61) Antibody, clone SAP

05-769
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-769
      Replaces04-1060
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Integrin β3 (CD61) Antibody, clone SAP
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
      Applications
      ApplicationAnti-Integrin β3 (CD61) Antibody, clone SAP detects level of Integrin β3 (CD61) & has been published & validated for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Biological Information
      ImmunogenHuman platelet membrane fractions
      Cloneclone SAP
      HostMouse
      SpecificityIntegrin β3
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
      Gene Symbol
      • ITGB3
      • GP3A
      • GPIIIa
      • CD61
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05106 # Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 788 amino acids; 87058 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
      PTM: Phosphorylated on tyrosine residues in response to thrombin- induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. SHC binding also occurs when Tyr-785 alone is phosphorylated.
      DISEASE: SwissProt: P05106 # Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.
      SIMILARITY: SwissProt: P05106 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
      Molecular WeightMr ~115kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunocytochemistry
      Sales RestrictionsDue to license agreement restrictions, this product cannot be purchased for resale.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Integrin #946;3 (CD61), clone SAP (mouse monoclonal IgG1#954;) - 2123170 2123170
      Anti-Integrin #946;3 (CD61), clone SAP (mouse monoclonal IgG1#954;) - 2135167 2135167
      Anti-Integrin #946;3 (CD61), clone SAP (mouse monoclonal IgG1#954;) - 2154182 2154182
      Anti-Integrin b3 (CD61), clone SAP (mouse monoclonal IgG1k) - 2243477 2243477
      Anti-Integrin b3 (CD61), clone SAP (mouse monoclonal IgG1k) - 2297224 2297224
      Anti-Integrin b3 (CD61), clone SAP - 2052865 2052865
      Anti-Integrin b3 (CD61), clone SAP - DAM1541092 DAM1541092
      Anti-Integrin b3 (CD61), clone SAP - DAM1683498 DAM1683498
      Anti-Integrin b3 (CD61), clone SAP - JBC1884527 JBC1884527
      Anti-Integrin beta;3 (CD61), clone SAP - 26804 26804

      References

      Reference overviewPub Med ID
      Anti-integrin therapy.
      Hamm, Christian W
      Annu. Rev. Med., 54: 425-35 (2003)  2003

      Show Abstract
      12414914 12414914
      Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis.
      Kumar, C Chandra
      Current drug targets, 4: 123-31 (2003)  2003

      Show Abstract
      12558065 12558065

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      Life Science Research > Antibodies and Assays > Primary Antibodies