04-001 | Anti-JAK2 Antibody, clone 8E10.2

04-001
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-001
      Trade Name
      • Upstate
      DescriptionAnti-JAK2 Antibody, clone 8E10.2
      Alternate Names
      • Janus kinase 2
      • Tyrosine kinase
      Background InformationJAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerizes and translocates to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
      References
      Product Information
      FormatPurified
      Control
      • L6 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl with 0.05% sodium azide
      Applications
      ApplicationAnti-JAK2 Antibody, clone 8E10.2 detects level of JAK2 & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blot Analysis: 0.5-1 μg/mL of this lot was used to detect Jak2 in L6 cell lysates.

      Immunohistochemistry(Paraffin):
      A previous lot of this antibody was used in immunohistochemistry(paraffin) staining with eptiope retrieval: Human Cancer Array.
      Biological Information
      ImmunogenKLH-conjugated linear peptide.
      Clone8E10.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes Jak2.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq]
      Gene Symbol
      • JAK2
      • JAK-2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight130 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on L6 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-JAK2, clone 8E10.2 (mouse monoclonal) Monoclonal Antibody Q2922287
      Anti-JAK2, clone 8E10.2 - 2148289 2148289
      Anti-JAK2, clone 8E10.2 - 2387804 2387804
      Anti-JAK2, clone 8E10.2 - 2228135 2228135
      Anti-JAK2, clone 8E10.2 - NG1561223 NG1561223
      Anti-JAK2, clone 8E10.2 - NG1652813 NG1652813
      Anti-JAK2, clone 8E10.2 - NG1692770 NG1692770
      Anti-JAK2, clone 8E10.2 - NG1734236 NG1734236
      Anti-JAK2, clone 8E10.2 - NG1800807 NG1800807
      Anti-JAK2, clone 8E10.2 - NG1897886 NG1897886

      References

      Reference overviewApplicationPub Med ID
      Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.
      Vujanovic L, Szymkowski DE, Alber S, Watkins SC, Vujanovic NL, Butterfield LH
      Blood  116  575-83. Epub 2010 Apr 29.  2010

      Show Abstract
      20430958 20430958
      The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression.
      Korzus, E, et al.
      J. Biol. Chem., 272: 1188-96 (1997)  1997

      Show Abstract
      Immunoprecipitation, Immunoblotting (Western)8995420 8995420

      Technical Info

      Title
      JAK/STAT Signaling Research Focus

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies